Altered levels of salivary biochemical markers in periodontitis

Zohreh Khodaii, Mahboobeh Mehrabani, Nasrin Rafieian, Gholam Ali Najafi-Parizi, Ahmadreza Mirzaei, Reza Akbarzadeh*

*Corresponding author for this work
3 Citations (Scopus)


Purpose: To investigate the association between periodontitis and levels of biochemical markers as well as enzyme activity. Methods: Unstimulated whole saliva samples were obtained from 30 patients with periodontitis. Biochemical factors including the levels of malondialdehyde (MDA), superoxide dismutase (SOD), nitric oxide (NO), uric acid (UA), and lactoferrin, as well as P-hexosaminidase (p-HEX) activity were measured. Results: The levels of a salivary oxidant such as MDA and NO were statistically significantly higher in periodontitis patients than to that of healthy individuals. Similarly, the results indicated elevated levels of lactoferrin and p-HEX activity in saliva of the periodontitis group, which was statistically significant when compared to the controls. While the levels of an enzymatic antioxidant such as SOD were higher in the periodontitis patients than in the control subjects, uric acid levels were statistically significantly lower in the saliva of the periodontitis patients than in the healthy controls.

Original languageEnglish
JournalAmerican Journal of Dentistry
Issue number4
Pages (from-to)183-186
Number of pages4
Publication statusPublished - 08.2019

Research Areas and Centers

  • Academic Focus: Center for Infection and Inflammation Research (ZIEL)


Dive into the research topics of 'Altered levels of salivary biochemical markers in periodontitis'. Together they form a unique fingerprint.

Cite this