Alterations in the phenotype of CMV-specific and total CD8
                        +
                         T-cell populations in Wegener's granulomatosis

Peter Lamprecht; Ana L. Vargas Cuero; Antje Muller; Elena Csernok; Jan Voswinkel; Matthias Maass; Werner Solbach; Wolfgang L. Gross; Paul Klenerman

doi:10.1016/j.cellimm.2003.08.003

Alterations in the phenotype of CMV-specific and total CD8 ⁺ T-cell populations in Wegener's granulomatosis

Peter Lamprecht^*, Ana L. Vargas Cuero, Antje Muller, Elena Csernok, Jan Voswinkel, Matthias Maass, Werner Solbach, Wolfgang L. Gross, Paul Klenerman

^*Corresponding author for this work

Clinic of Rheumatology

11 Citations (Scopus)

Abstract

Wegener's granulomatosis (WG) is an autoimmune disease of as yet unknown etiology. To date it has remained obscure what causes WG or determines disease progression. Case reports suggest that viral infections such as cytomegalovirus (CMV) reactivation may contribute to disease flares. In this study we found a skewing of the phenotype of CMV-specific CD8 ⁺ tet(ramer) ⁺ T-cells in WG. A marked proportion of these cells displayed a late differentiated "effector memory" T-cell phenotype with decreased expression of CD28 and CD62L, and heterogeneous CD27 expression, features which were also seen in CD8 ⁺ tet ^- T-cells in WG, but not in controls. Our results might reflect profound generalized changes in the CD8 ⁺ T-cell compartment also affecting virus-specific T-cell responses in WG.

Original language	English
Journal	Cellular Immunology
Volume	224
Issue number	1
Pages (from-to)	1-7
Number of pages	7
ISSN	0008-8749
DOIs	https://doi.org/10.1016/j.cellimm.2003.08.003
Publication status	Published - 01.01.2003

Funding

Supported by Grants SFB367/A8 (P.L., A.M., W.L.G.), SFB367/A11 (J.V.) and SFB367/B11 (M.M.) from the German Research Society (Deutsche Forschungsgemeinschaft/DFG), Grants No. 0.2 and 02.2 from the Verein zur Foerderung der Erforschung und Bekaempfung rheumatischer Erkrankungen Bad Bramstedt e.V. (A.M., P.L.), Welcome trust and the Medical Research Council, UK (P.K.).

Research Areas and Centers

Academic Focus: Center for Infection and Inflammation Research (ZIEL)

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1016/j.cellimm.2003.08.003

Cite this

Lamprecht, P., Vargas Cuero, A. L., Muller, A., Csernok, E., Voswinkel, J., Maass, M., Solbach, W., Gross, W. L., & Klenerman, P. (2003). Alterations in the phenotype of CMV-specific and total CD8 ⁺ T-cell populations in Wegener's granulomatosis. Cellular Immunology, 224(1), 1-7. https://doi.org/10.1016/j.cellimm.2003.08.003

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title = "Alterations in the phenotype of CMV-specific and total CD8 + T-cell populations in Wegener's granulomatosis",

abstract = " Wegener's granulomatosis (WG) is an autoimmune disease of as yet unknown etiology. To date it has remained obscure what causes WG or determines disease progression. Case reports suggest that viral infections such as cytomegalovirus (CMV) reactivation may contribute to disease flares. In this study we found a skewing of the phenotype of CMV-specific CD8 + tet(ramer) + T-cells in WG. A marked proportion of these cells displayed a late differentiated {"}effector memory{"} T-cell phenotype with decreased expression of CD28 and CD62L, and heterogeneous CD27 expression, features which were also seen in CD8 + tet - T-cells in WG, but not in controls. Our results might reflect profound generalized changes in the CD8 + T-cell compartment also affecting virus-specific T-cell responses in WG.",

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Lamprecht, P, Vargas Cuero, AL, Muller, A, Csernok, E, Voswinkel, J, Maass, M, Solbach, W, Gross, WL & Klenerman, P 2003, 'Alterations in the phenotype of CMV-specific and total CD8 ⁺ T-cell populations in Wegener's granulomatosis', Cellular Immunology, vol. 224, no. 1, pp. 1-7. https://doi.org/10.1016/j.cellimm.2003.08.003

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AU - Lamprecht, Peter

AU - Vargas Cuero, Ana L.

AU - Muller, Antje

AU - Csernok, Elena

AU - Voswinkel, Jan

AU - Maass, Matthias

AU - Solbach, Werner

AU - Gross, Wolfgang L.

AU - Klenerman, Paul

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AB - Wegener's granulomatosis (WG) is an autoimmune disease of as yet unknown etiology. To date it has remained obscure what causes WG or determines disease progression. Case reports suggest that viral infections such as cytomegalovirus (CMV) reactivation may contribute to disease flares. In this study we found a skewing of the phenotype of CMV-specific CD8 + tet(ramer) + T-cells in WG. A marked proportion of these cells displayed a late differentiated "effector memory" T-cell phenotype with decreased expression of CD28 and CD62L, and heterogeneous CD27 expression, features which were also seen in CD8 + tet - T-cells in WG, but not in controls. Our results might reflect profound generalized changes in the CD8 + T-cell compartment also affecting virus-specific T-cell responses in WG.

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