Almost normal cognitive function in patients during therapy for childhood acute lymphoblastic leukemia without cranial irradiation according to ALL-BFM 95 and COALL 06-97 protocols: Results of an Austrian-German multicenter longitudinal study and implications for follow-up

Paul Krappmann; Marios Paulides; Wolfgang Stöhr; Edith Ittner; Bernhard Plattig; Petra Nickel; Herwig Lackner; Martin Schrappe; Gritta Janka; Jörn D. Beck; Thorsten Langer

doi:10.1080/08880010601123281

Almost normal cognitive function in patients during therapy for childhood acute lymphoblastic leukemia without cranial irradiation according to ALL-BFM 95 and COALL 06-97 protocols: Results of an Austrian-German multicenter longitudinal study and implications for follow-up

Paul Krappmann, Marios Paulides, Wolfgang Stöhr, Edith Ittner, Bernhard Plattig, Petra Nickel, Herwig Lackner, Martin Schrappe, Gritta Janka, Jörn D. Beck, Thorsten Langer^*

^*Corresponding author for this work

Clinic of Pediatric and Adolescent Medicine

24 Citations (Scopus)

Abstract

In a multicenter study the authors prospectively investigated neurocognitive function in childhood ALL patients. Sixty-six patients (mean age at diagnosis 7.9 ± 3.6 years, 34 female), treated with repeated intrathecal and systemical methotrexate administrations without cranial irradiation, underwent psychometric testing for intelligence, concentration, and visual-motor integration postdiagnosis and after reinduction therapy. Although there was a statistically significant decline of intellectual function after reinduction therapy for younger patients and girls (IQ scores still within normative data range), there were no differences in visual-motor performance and concentration over the time of induction therapy. Thus, neurocognitive examination should focus on younger ALL patients and girls.

Original language	English
Journal	Pediatric Hematology and Oncology
Volume	24
Issue number	2
Pages (from-to)	101-109
Number of pages	9
ISSN	0888-0018
DOIs	https://doi.org/10.1080/08880010601123281
Publication status	Published - 02.2007

Funding

Received 21 March 2006; accepted 13 November 2006. Paul Krappmann and Marios Paulides contributed equally to this paper. The investigation was supported by the Erlanger Leistungsbezogene Anschubfinanzierung und Nachwuchsförderung (ELAN) and the Deutsche Leukämie Forschungshilfe. We wish to thank the participating centers. Address correspondence to PD Dr. med. Th. Langer, Abteilung für Immunologie und Onkologie, Universitäts-Kinder-und Jugendklinik, Loschgestraße 15, 91054 Erlangen, Germany. E-mail: less@ kinder.imed.uni-erlangen.de

Research Areas and Centers

Academic Focus: Center for Brain, Behavior and Metabolism (CBBM)

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1080/08880010601123281

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Krappmann, P., Paulides, M., Stöhr, W., Ittner, E., Plattig, B., Nickel, P., Lackner, H., Schrappe, M., Janka, G., Beck, J. D., & Langer, T. (2007). Almost normal cognitive function in patients during therapy for childhood acute lymphoblastic leukemia without cranial irradiation according to ALL-BFM 95 and COALL 06-97 protocols: Results of an Austrian-German multicenter longitudinal study and implications for follow-up. Pediatric Hematology and Oncology, 24(2), 101-109. https://doi.org/10.1080/08880010601123281

Krappmann, Paul ; Paulides, Marios ; Stöhr, Wolfgang et al. / Almost normal cognitive function in patients during therapy for childhood acute lymphoblastic leukemia without cranial irradiation according to ALL-BFM 95 and COALL 06-97 protocols: Results of an Austrian-German multicenter longitudinal study and implications for follow-up. In: Pediatric Hematology and Oncology. 2007 ; Vol. 24, No. 2. pp. 101-109.

@article{26cda6045018410cb8884caeb54a4aaf,

title = "Almost normal cognitive function in patients during therapy for childhood acute lymphoblastic leukemia without cranial irradiation according to ALL-BFM 95 and COALL 06-97 protocols: Results of an Austrian-German multicenter longitudinal study and implications for follow-up",

abstract = "In a multicenter study the authors prospectively investigated neurocognitive function in childhood ALL patients. Sixty-six patients (mean age at diagnosis 7.9 ± 3.6 years, 34 female), treated with repeated intrathecal and systemical methotrexate administrations without cranial irradiation, underwent psychometric testing for intelligence, concentration, and visual-motor integration postdiagnosis and after reinduction therapy. Although there was a statistically significant decline of intellectual function after reinduction therapy for younger patients and girls (IQ scores still within normative data range), there were no differences in visual-motor performance and concentration over the time of induction therapy. Thus, neurocognitive examination should focus on younger ALL patients and girls.",

author = "Paul Krappmann and Marios Paulides and Wolfgang St{\"o}hr and Edith Ittner and Bernhard Plattig and Petra Nickel and Herwig Lackner and Martin Schrappe and Gritta Janka and Beck, \{J{\"o}rn D.\} and Thorsten Langer",

note = "Funding Information: Received 21 March 2006; accepted 13 November 2006. Paul Krappmann and Marios Paulides contributed equally to this paper. The investigation was supported by the Erlanger Leistungsbezogene Anschubfinanzierung und Nachwuchsf{\"o}rderung (ELAN) and the Deutsche Leuk{\"a}mie Forschungshilfe. We wish to thank the participating centers. Address correspondence to PD Dr. med. Th. Langer, Abteilung f{\"u}r Immunologie und Onkologie, Universit{\"a}ts-Kinder-und Jugendklinik, Loschgestra{\ss}e 15, 91054 Erlangen, Germany. E-mail: less@ kinder.imed.uni-erlangen.de Copyright: Copyright 2018 Elsevier B.V., All rights reserved.",

year = "2007",

month = feb,

doi = "10.1080/08880010601123281",

language = "English",

volume = "24",

pages = "101--109",

journal = "Pediatric Hematology and Oncology",

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Krappmann, P, Paulides, M, Stöhr, W, Ittner, E, Plattig, B, Nickel, P, Lackner, H, Schrappe, M, Janka, G, Beck, JD & Langer, T 2007, 'Almost normal cognitive function in patients during therapy for childhood acute lymphoblastic leukemia without cranial irradiation according to ALL-BFM 95 and COALL 06-97 protocols: Results of an Austrian-German multicenter longitudinal study and implications for follow-up', Pediatric Hematology and Oncology, vol. 24, no. 2, pp. 101-109. https://doi.org/10.1080/08880010601123281

Almost normal cognitive function in patients during therapy for childhood acute lymphoblastic leukemia without cranial irradiation according to ALL-BFM 95 and COALL 06-97 protocols: Results of an Austrian-German multicenter longitudinal study and implications for follow-up. / Krappmann, Paul; Paulides, Marios; Stöhr, Wolfgang et al.
In: Pediatric Hematology and Oncology, Vol. 24, No. 2, 02.2007, p. 101-109.

Research output: Journal Articles › Journal articles › Research › peer-review

TY - JOUR

T1 - Almost normal cognitive function in patients during therapy for childhood acute lymphoblastic leukemia without cranial irradiation according to ALL-BFM 95 and COALL 06-97 protocols: Results of an Austrian-German multicenter longitudinal study and implications for follow-up

AU - Krappmann, Paul

AU - Paulides, Marios

AU - Stöhr, Wolfgang

AU - Ittner, Edith

AU - Plattig, Bernhard

AU - Nickel, Petra

AU - Lackner, Herwig

AU - Schrappe, Martin

AU - Janka, Gritta

AU - Beck, Jörn D.

AU - Langer, Thorsten

N1 - Funding Information: Received 21 March 2006; accepted 13 November 2006. Paul Krappmann and Marios Paulides contributed equally to this paper. The investigation was supported by the Erlanger Leistungsbezogene Anschubfinanzierung und Nachwuchsförderung (ELAN) and the Deutsche Leukämie Forschungshilfe. We wish to thank the participating centers. Address correspondence to PD Dr. med. Th. Langer, Abteilung für Immunologie und Onkologie, Universitäts-Kinder-und Jugendklinik, Loschgestraße 15, 91054 Erlangen, Germany. E-mail: less@ kinder.imed.uni-erlangen.de Copyright: Copyright 2018 Elsevier B.V., All rights reserved.

PY - 2007/2

Y1 - 2007/2

N2 - In a multicenter study the authors prospectively investigated neurocognitive function in childhood ALL patients. Sixty-six patients (mean age at diagnosis 7.9 ± 3.6 years, 34 female), treated with repeated intrathecal and systemical methotrexate administrations without cranial irradiation, underwent psychometric testing for intelligence, concentration, and visual-motor integration postdiagnosis and after reinduction therapy. Although there was a statistically significant decline of intellectual function after reinduction therapy for younger patients and girls (IQ scores still within normative data range), there were no differences in visual-motor performance and concentration over the time of induction therapy. Thus, neurocognitive examination should focus on younger ALL patients and girls.

AB - In a multicenter study the authors prospectively investigated neurocognitive function in childhood ALL patients. Sixty-six patients (mean age at diagnosis 7.9 ± 3.6 years, 34 female), treated with repeated intrathecal and systemical methotrexate administrations without cranial irradiation, underwent psychometric testing for intelligence, concentration, and visual-motor integration postdiagnosis and after reinduction therapy. Although there was a statistically significant decline of intellectual function after reinduction therapy for younger patients and girls (IQ scores still within normative data range), there were no differences in visual-motor performance and concentration over the time of induction therapy. Thus, neurocognitive examination should focus on younger ALL patients and girls.

UR - https://www.scopus.com/pages/publications/34247158203

U2 - 10.1080/08880010601123281

DO - 10.1080/08880010601123281

M3 - Journal articles

C2 - 17454775

AN - SCOPUS:34247158203

SN - 0888-0018

VL - 24

SP - 101

EP - 109

JO - Pediatric Hematology and Oncology

JF - Pediatric Hematology and Oncology

IS - 2

ER -

Krappmann P, Paulides M, Stöhr W, Ittner E, Plattig B, Nickel P et al. Almost normal cognitive function in patients during therapy for childhood acute lymphoblastic leukemia without cranial irradiation according to ALL-BFM 95 and COALL 06-97 protocols: Results of an Austrian-German multicenter longitudinal study and implications for follow-up. Pediatric Hematology and Oncology. 2007 Feb;24(2):101-109. doi: 10.1080/08880010601123281

Almost normal cognitive function in patients during therapy for childhood acute lymphoblastic leukemia without cranial irradiation according to ALL-BFM 95 and COALL 06-97 protocols: Results of an Austrian-German multicenter longitudinal study and implications for follow-up

Abstract

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UN SDGs

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