TY - JOUR
T1 - Almost normal cognitive function in patients during therapy for childhood acute lymphoblastic leukemia without cranial irradiation according to ALL-BFM 95 and COALL 06-97 protocols: Results of an Austrian-German multicenter longitudinal study and implications for follow-up
AU - Krappmann, Paul
AU - Paulides, Marios
AU - Stöhr, Wolfgang
AU - Ittner, Edith
AU - Plattig, Bernhard
AU - Nickel, Petra
AU - Lackner, Herwig
AU - Schrappe, Martin
AU - Janka, Gritta
AU - Beck, Jörn D.
AU - Langer, Thorsten
N1 - Funding Information:
Received 21 March 2006; accepted 13 November 2006. Paul Krappmann and Marios Paulides contributed equally to this paper. The investigation was supported by the Erlanger Leistungsbezogene Anschubfinanzierung und Nachwuchsförderung (ELAN) and the Deutsche Leukämie Forschungshilfe. We wish to thank the participating centers. Address correspondence to PD Dr. med. Th. Langer, Abteilung für Immunologie und Onkologie, Universitäts-Kinder-und Jugendklinik, Loschgestraße 15, 91054 Erlangen, Germany. E-mail: less@ kinder.imed.uni-erlangen.de
Copyright:
Copyright 2018 Elsevier B.V., All rights reserved.
PY - 2007/2
Y1 - 2007/2
N2 - In a multicenter study the authors prospectively investigated neurocognitive function in childhood ALL patients. Sixty-six patients (mean age at diagnosis 7.9 ± 3.6 years, 34 female), treated with repeated intrathecal and systemical methotrexate administrations without cranial irradiation, underwent psychometric testing for intelligence, concentration, and visual-motor integration postdiagnosis and after reinduction therapy. Although there was a statistically significant decline of intellectual function after reinduction therapy for younger patients and girls (IQ scores still within normative data range), there were no differences in visual-motor performance and concentration over the time of induction therapy. Thus, neurocognitive examination should focus on younger ALL patients and girls.
AB - In a multicenter study the authors prospectively investigated neurocognitive function in childhood ALL patients. Sixty-six patients (mean age at diagnosis 7.9 ± 3.6 years, 34 female), treated with repeated intrathecal and systemical methotrexate administrations without cranial irradiation, underwent psychometric testing for intelligence, concentration, and visual-motor integration postdiagnosis and after reinduction therapy. Although there was a statistically significant decline of intellectual function after reinduction therapy for younger patients and girls (IQ scores still within normative data range), there were no differences in visual-motor performance and concentration over the time of induction therapy. Thus, neurocognitive examination should focus on younger ALL patients and girls.
UR - http://www.scopus.com/inward/record.url?scp=34247158203&partnerID=8YFLogxK
U2 - 10.1080/08880010601123281
DO - 10.1080/08880010601123281
M3 - Journal articles
C2 - 17454775
AN - SCOPUS:34247158203
SN - 0888-0018
VL - 24
SP - 101
EP - 109
JO - Pediatric Hematology and Oncology
JF - Pediatric Hematology and Oncology
IS - 2
ER -
