Allergische Soforttypreaktionen und kreuzreaktive Kohlenhydratepitope (CCD)

Uta Jappe; Arnd Petersen; Monika Raulf-Heimsoth

doi:10.1007/s15007-013-0015-5

Allergische Soforttypreaktionen und kreuzreaktive Kohlenhydratepitope (CCD)

Translated title of the contribution: Immediate-type reactions and cross-reactive carbohydrate determinants (CCD)

Uta Jappe^*, Arnd Petersen, Monika Raulf-Heimsoth

^*Corresponding author for this work

23 Citations (Scopus)

Abstract

Many plant allergens are glykoproteins. IgE-reactivity to the respective glykan moiety seldom seems to be of clinical significance. This appears to be different for a carbohydrate expressed on cells of non-primate mammals, prosimians and New World monkeys, the galactose-α-1,3-galactose (α-Gal). IgE-antibodies specific for α-Gal (anti-α-Gal-IgE) are associated with severe allergic symptoms and with a delayed-type anaphylaxis. The allergologically relevant carbohydrate determinants, therefore, differ considerably with regard to structure, occurrence, their association with clinical symptoms and the degree of severity.

Translated title of the contribution	Immediate-type reactions and cross-reactive carbohydrate determinants (CCD)
Original language	German
Journal	Allergo Journal
Volume	22
Issue number	1
Pages (from-to)	25-32
Number of pages	8
ISSN	0941-8849
DOIs	https://doi.org/10.1007/s15007-013-0015-5
Publication status	Published - 01.01.2013
Externally published	Yes

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abstract = "Many plant allergens are glykoproteins. IgE-reactivity to the respective glykan moiety seldom seems to be of clinical significance. This appears to be different for a carbohydrate expressed on cells of non-primate mammals, prosimians and New World monkeys, the galactose-α-1,3-galactose (α-Gal). IgE-antibodies specific for α-Gal (anti-α-Gal-IgE) are associated with severe allergic symptoms and with a delayed-type anaphylaxis. The allergologically relevant carbohydrate determinants, therefore, differ considerably with regard to structure, occurrence, their association with clinical symptoms and the degree of severity. ",

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AU - Jappe, Uta

AU - Petersen, Arnd

AU - Raulf-Heimsoth, Monika

PY - 2013/1/1

Y1 - 2013/1/1

N2 - Many plant allergens are glykoproteins. IgE-reactivity to the respective glykan moiety seldom seems to be of clinical significance. This appears to be different for a carbohydrate expressed on cells of non-primate mammals, prosimians and New World monkeys, the galactose-α-1,3-galactose (α-Gal). IgE-antibodies specific for α-Gal (anti-α-Gal-IgE) are associated with severe allergic symptoms and with a delayed-type anaphylaxis. The allergologically relevant carbohydrate determinants, therefore, differ considerably with regard to structure, occurrence, their association with clinical symptoms and the degree of severity.

AB - Many plant allergens are glykoproteins. IgE-reactivity to the respective glykan moiety seldom seems to be of clinical significance. This appears to be different for a carbohydrate expressed on cells of non-primate mammals, prosimians and New World monkeys, the galactose-α-1,3-galactose (α-Gal). IgE-antibodies specific for α-Gal (anti-α-Gal-IgE) are associated with severe allergic symptoms and with a delayed-type anaphylaxis. The allergologically relevant carbohydrate determinants, therefore, differ considerably with regard to structure, occurrence, their association with clinical symptoms and the degree of severity.

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ER -

Allergische Soforttypreaktionen und kreuzreaktive Kohlenhydratepitope (CCD)

Abstract

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