Alcoholism, craving, and hormones: The role of leptin, ghrelin, prolactin, and the pro-opiomelanocortin system in modulating ethanol intake

Friedrich Martin Wurst; Dennis D. Rasmussen; Thomas Hillemacher; Thomas Kraus; Katrin Ramskogler; Otto Lesch; Kristina Bayerlein; Anja Schanze; Julia Wilhelm; Klaus Junghanns; Tilman Schulte; Gerhard Dammann; Lutz Pridzun; Gerhard Wiesbeck; Johannes Kornhuber; Stefan Bleich

doi:10.1111/j.1530-0277.2007.00531.x

Alcoholism, craving, and hormones: The role of leptin, ghrelin, prolactin, and the pro-opiomelanocortin system in modulating ethanol intake

Friedrich Martin Wurst^*, Dennis D. Rasmussen, Thomas Hillemacher, Thomas Kraus, Katrin Ramskogler, Otto Lesch, Kristina Bayerlein, Anja Schanze, Julia Wilhelm, Klaus Junghanns, Tilman Schulte, Gerhard Dammann, Lutz Pridzun, Gerhard Wiesbeck, Johannes Kornhuber, Stefan Bleich

^*Corresponding author for this work

Clinic of Psychiatry and Psychotherapy

32 Citations (Scopus)

Abstract

Evidence is growing that appetite regulating peptides such as leptin and ghrelin, but also other hormones including prolactin are altered in alcoholism. The brain pro-opiomelanocortin (POMC) system which has important mediating roles in alcohol intake also has important functions in prolactin regulation and energy homeostasis. Furthermore, it has been demonstrated to be functionally integrated with leptin regulation. The satiety factor leptin seems to be counteracted by the gut-derived peptide ghrelin which increases hunger and food intake. Consequently, the POMC system may have a role in integrating regulation of alcohol effects and these seemingly disparate regulatory systems. The goal of this mini-review is to discuss the results of some recent investigations of the potential interactions of these systems with acute and chronic alcohol responses.

Original language	English
Journal	Alcoholism: Clinical and Experimental Research
Volume	31
Issue number	12
Pages (from-to)	1963-1967
Number of pages	5
ISSN	0145-6008
DOIs	https://doi.org/10.1111/j.1530-0277.2007.00531.x
Publication status	Published - 12.2007

Research Areas and Centers

Academic Focus: Center for Brain, Behavior and Metabolism (CBBM)

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This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1111/j.1530-0277.2007.00531.x

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Wurst, F. M., Rasmussen, D. D., Hillemacher, T., Kraus, T., Ramskogler, K., Lesch, O., Bayerlein, K., Schanze, A., Wilhelm, J., Junghanns, K., Schulte, T., Dammann, G., Pridzun, L., Wiesbeck, G., Kornhuber, J., & Bleich, S. (2007). Alcoholism, craving, and hormones: The role of leptin, ghrelin, prolactin, and the pro-opiomelanocortin system in modulating ethanol intake. Alcoholism: Clinical and Experimental Research, 31(12), 1963-1967. https://doi.org/10.1111/j.1530-0277.2007.00531.x

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title = "Alcoholism, craving, and hormones: The role of leptin, ghrelin, prolactin, and the pro-opiomelanocortin system in modulating ethanol intake",

abstract = "Evidence is growing that appetite regulating peptides such as leptin and ghrelin, but also other hormones including prolactin are altered in alcoholism. The brain pro-opiomelanocortin (POMC) system which has important mediating roles in alcohol intake also has important functions in prolactin regulation and energy homeostasis. Furthermore, it has been demonstrated to be functionally integrated with leptin regulation. The satiety factor leptin seems to be counteracted by the gut-derived peptide ghrelin which increases hunger and food intake. Consequently, the POMC system may have a role in integrating regulation of alcohol effects and these seemingly disparate regulatory systems. The goal of this mini-review is to discuss the results of some recent investigations of the potential interactions of these systems with acute and chronic alcohol responses.",

author = "Wurst, {Friedrich Martin} and Rasmussen, {Dennis D.} and Thomas Hillemacher and Thomas Kraus and Katrin Ramskogler and Otto Lesch and Kristina Bayerlein and Anja Schanze and Julia Wilhelm and Klaus Junghanns and Tilman Schulte and Gerhard Dammann and Lutz Pridzun and Gerhard Wiesbeck and Johannes Kornhuber and Stefan Bleich",

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doi = "10.1111/j.1530-0277.2007.00531.x",

language = "English",

volume = "31",

pages = "1963--1967",

journal = "Alcoholism: Clinical and Experimental Research",

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Wurst, FM, Rasmussen, DD, Hillemacher, T, Kraus, T, Ramskogler, K, Lesch, O, Bayerlein, K, Schanze, A, Wilhelm, J, Junghanns, K, Schulte, T, Dammann, G, Pridzun, L, Wiesbeck, G, Kornhuber, J & Bleich, S 2007, 'Alcoholism, craving, and hormones: The role of leptin, ghrelin, prolactin, and the pro-opiomelanocortin system in modulating ethanol intake', Alcoholism: Clinical and Experimental Research, vol. 31, no. 12, pp. 1963-1967. https://doi.org/10.1111/j.1530-0277.2007.00531.x

Alcoholism, craving, and hormones: The role of leptin, ghrelin, prolactin, and the pro-opiomelanocortin system in modulating ethanol intake. / Wurst, Friedrich Martin; Rasmussen, Dennis D.; Hillemacher, Thomas et al.
In: Alcoholism: Clinical and Experimental Research, Vol. 31, No. 12, 12.2007, p. 1963-1967.

Research output: Journal Articles › Short survey › peer-review

TY - JOUR

T1 - Alcoholism, craving, and hormones: The role of leptin, ghrelin, prolactin, and the pro-opiomelanocortin system in modulating ethanol intake

AU - Wurst, Friedrich Martin

AU - Rasmussen, Dennis D.

AU - Hillemacher, Thomas

AU - Kraus, Thomas

AU - Ramskogler, Katrin

AU - Lesch, Otto

AU - Bayerlein, Kristina

AU - Schanze, Anja

AU - Wilhelm, Julia

AU - Junghanns, Klaus

AU - Schulte, Tilman

AU - Dammann, Gerhard

AU - Pridzun, Lutz

AU - Wiesbeck, Gerhard

AU - Kornhuber, Johannes

AU - Bleich, Stefan

PY - 2007/12

Y1 - 2007/12

N2 - Evidence is growing that appetite regulating peptides such as leptin and ghrelin, but also other hormones including prolactin are altered in alcoholism. The brain pro-opiomelanocortin (POMC) system which has important mediating roles in alcohol intake also has important functions in prolactin regulation and energy homeostasis. Furthermore, it has been demonstrated to be functionally integrated with leptin regulation. The satiety factor leptin seems to be counteracted by the gut-derived peptide ghrelin which increases hunger and food intake. Consequently, the POMC system may have a role in integrating regulation of alcohol effects and these seemingly disparate regulatory systems. The goal of this mini-review is to discuss the results of some recent investigations of the potential interactions of these systems with acute and chronic alcohol responses.

AB - Evidence is growing that appetite regulating peptides such as leptin and ghrelin, but also other hormones including prolactin are altered in alcoholism. The brain pro-opiomelanocortin (POMC) system which has important mediating roles in alcohol intake also has important functions in prolactin regulation and energy homeostasis. Furthermore, it has been demonstrated to be functionally integrated with leptin regulation. The satiety factor leptin seems to be counteracted by the gut-derived peptide ghrelin which increases hunger and food intake. Consequently, the POMC system may have a role in integrating regulation of alcohol effects and these seemingly disparate regulatory systems. The goal of this mini-review is to discuss the results of some recent investigations of the potential interactions of these systems with acute and chronic alcohol responses.

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DO - 10.1111/j.1530-0277.2007.00531.x

M3 - Short survey

C2 - 18034691

AN - SCOPUS:36348941048

SN - 0145-6008

VL - 31

SP - 1963

EP - 1967

JO - Alcoholism: Clinical and Experimental Research

JF - Alcoholism: Clinical and Experimental Research

IS - 12

ER -

Alcoholism, craving, and hormones: The role of leptin, ghrelin, prolactin, and the pro-opiomelanocortin system in modulating ethanol intake

Abstract

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UN SDGs

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