Abstract
The cell surface expression of receptors for TGF-β was studied in human osteoblasts derived from femoral trabecular bone of a total of 19 patients aged 2-83 years. All cell populations investigated showed a similar profile of expression of TGF-β receptors (TβR) I, II and III (betaglycan). There were no significant differences in cell differentiation or proliferative behaviour between the age groups. The TGF-β receptor number per cell significantly increased with age, while the receptor affinity tended to decrease. IGF-I did not influence TβR expression in vitro. The results indicate an age-dependent and IGF-I independent increase of osteoblastic TGF-β receptors in human osteoblastlike cells in vitro.
| Original language | English |
|---|---|
| Journal | Experimental and Clinical Endocrinology and Diabetes |
| Volume | 108 |
| Issue number | 4 |
| Pages (from-to) | 311-315 |
| Number of pages | 5 |
| ISSN | 0947-7349 |
| DOIs | |
| Publication status | Published - 27.07.2000 |
UN SDGs
This output contributes to the following UN Sustainable Development Goals (SDGs)
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SDG 3 Good Health and Well-being
Research Areas and Centers
- Academic Focus: Center for Infection and Inflammation Research (ZIEL)
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