Age-related differences in the expression of receptors for TGF-β in human osteoblast-like cells in vitro

B. Bätge; A. Feydt; J. Gebken; H. Klein; H. Notbohm; P. K. Müller; J. Brinckmann

doi:10.1055/s-2000-8001

Age-related differences in the expression of receptors for TGF-β in human osteoblast-like cells in vitro

B. Bätge^*, A. Feydt, J. Gebken, H. Klein, H. Notbohm, P. K. Müller, J. Brinckmann

^*Corresponding author for this work

Klinikum Neustadt/Holstein

7 Citations (Scopus)

Abstract

The cell surface expression of receptors for TGF-β was studied in human osteoblasts derived from femoral trabecular bone of a total of 19 patients aged 2-83 years. All cell populations investigated showed a similar profile of expression of TGF-β receptors (TβR) I, II and III (betaglycan). There were no significant differences in cell differentiation or proliferative behaviour between the age groups. The TGF-β receptor number per cell significantly increased with age, while the receptor affinity tended to decrease. IGF-I did not influence TβR expression in vitro. The results indicate an age-dependent and IGF-I independent increase of osteoblastic TGF-β receptors in human osteoblastlike cells in vitro.

Original language	English
Journal	Experimental and Clinical Endocrinology and Diabetes
Volume	108
Issue number	4
Pages (from-to)	311-315
Number of pages	5
ISSN	0947-7349
DOIs	https://doi.org/10.1055/s-2000-8001
Publication status	Published - 27.07.2000

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Academic Focus: Center for Infection and Inflammation Research (ZIEL)

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title = "Age-related differences in the expression of receptors for TGF-β in human osteoblast-like cells in vitro",

abstract = "The cell surface expression of receptors for TGF-β was studied in human osteoblasts derived from femoral trabecular bone of a total of 19 patients aged 2-83 years. All cell populations investigated showed a similar profile of expression of TGF-β receptors (TβR) I, II and III (betaglycan). There were no significant differences in cell differentiation or proliferative behaviour between the age groups. The TGF-β receptor number per cell significantly increased with age, while the receptor affinity tended to decrease. IGF-I did not influence TβR expression in vitro. The results indicate an age-dependent and IGF-I independent increase of osteoblastic TGF-β receptors in human osteoblastlike cells in vitro.",

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T1 - Age-related differences in the expression of receptors for TGF-β in human osteoblast-like cells in vitro

AU - Bätge, B.

AU - Feydt, A.

AU - Gebken, J.

AU - Klein, H.

AU - Notbohm, H.

AU - Müller, P. K.

AU - Brinckmann, J.

PY - 2000/7/27

Y1 - 2000/7/27

N2 - The cell surface expression of receptors for TGF-β was studied in human osteoblasts derived from femoral trabecular bone of a total of 19 patients aged 2-83 years. All cell populations investigated showed a similar profile of expression of TGF-β receptors (TβR) I, II and III (betaglycan). There were no significant differences in cell differentiation or proliferative behaviour between the age groups. The TGF-β receptor number per cell significantly increased with age, while the receptor affinity tended to decrease. IGF-I did not influence TβR expression in vitro. The results indicate an age-dependent and IGF-I independent increase of osteoblastic TGF-β receptors in human osteoblastlike cells in vitro.

AB - The cell surface expression of receptors for TGF-β was studied in human osteoblasts derived from femoral trabecular bone of a total of 19 patients aged 2-83 years. All cell populations investigated showed a similar profile of expression of TGF-β receptors (TβR) I, II and III (betaglycan). There were no significant differences in cell differentiation or proliferative behaviour between the age groups. The TGF-β receptor number per cell significantly increased with age, while the receptor affinity tended to decrease. IGF-I did not influence TβR expression in vitro. The results indicate an age-dependent and IGF-I independent increase of osteoblastic TGF-β receptors in human osteoblastlike cells in vitro.

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SN - 0947-7349

VL - 108

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JO - Experimental and Clinical Endocrinology and Diabetes

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Age-related differences in the expression of receptors for TGF-β in human osteoblast-like cells in vitro

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