The cell surface expression of receptors for TGF-β was studied in human osteoblasts derived from femoral trabecular bone of a total of 19 patients aged 2-83 years. All cell populations investigated showed a similar profile of expression of TGF-β receptors (TβR) I, II and III (betaglycan). There were no significant differences in cell differentiation or proliferative behaviour between the age groups. The TGF-β receptor number per cell significantly increased with age, while the receptor affinity tended to decrease. IGF-I did not influence TβR expression in vitro. The results indicate an age-dependent and IGF-I independent increase of osteoblastic TGF-β receptors in human osteoblastlike cells in vitro.
|Journal||Experimental and Clinical Endocrinology and Diabetes|
|Number of pages||5|
|Publication status||Published - 27.07.2000|
Research Areas and Centers
- Academic Focus: Center for Infection and Inflammation Research (ZIEL)