Age, metabolic control and type of insulin regime influences health-related quality of life in children and adolescents with type 1 diabetes mellitus

Verena M. Wagner; Esther Müller–Godeffroy; Simone Von Sengbusch; Stefan Häger; Ute Thyen

doi:10.1007/s00431-005-1681-4

Age, metabolic control and type of insulin regime influences health-related quality of life in children and adolescents with type 1 diabetes mellitus

Verena M. Wagner^*, Esther Müller–Godeffroy, Simone Von Sengbusch, Stefan Häger, Ute Thyen

^*Corresponding author for this work

Department of Pediatric and Adolescent Medicine

87 Citations (Scopus)

Abstract

The effects of illness and treatment of diabetes mellitus extend beyond medical outcomes. We therefore evaluated health-related quality of life (HRQOL) in children (aged 8-12 years) and adolescents (aged 13-16 years) with type 1 diabetes to compare their results with healthy peers and to identify HRQOL determinants. A total of 68 children and adolescents from a tertiary care clinic which specialises in the management of diabetes, completed the generic KINDL-R questionnaire. This instrument for children and adolescents has six dimensions and an additional module assessing condition-related HRQOL. Overall, the HRQOL was not different between patients with type 1 diabetes and healthy controls. In some areas, children and adolescents with diabetes reported a better HRQOL compared to healthy peers: adolescents reported better psychological well-being ( P <0.05) and children higher levels of well-being in the school domain ( P <0.05). In general, children reported a better HRQOL ( P <0.05) than adolescents with type 1 diabetes confirming age-related differences in HRQOL in the general population. Lower HbA1c (<8%) and intensified insulin therapy (>3 injections/day) were associated with a better HRQOL in different domains ( P <0.05). The subscale "chronic illness" showed a better HRQOL ( P <0.001) in children and adolescents with diabetes compared to age-matched controls with other chronic conditions. Conclusion:Children and adolescents from a paediatric department specialising in diabetes management report good health-related quality of life. Younger age, good metabolic control and intensified insulin therapy are associated with a better health-related quality of life. Dimensions of health-related quality of life appear to play different roles at different ages, emphasising the importance of the multidimensional health-related quality of life concept and the value of age-appropriate self-reports.

Original language	English
Journal	European Journal of Pediatrics
Volume	164
Issue number	8
Pages (from-to)	491-496
Number of pages	6
ISSN	0340-6199
DOIs	https://doi.org/10.1007/s00431-005-1681-4
Publication status	Published - 07.2005

Funding

Acknowledgements This study was supported by grants from the Association for Support of Rehabilitation Research LVA Schle-swig-Holstein-vffr, Germany (Verein zur Förderung der Rehabili-tationsforschung). We would like to thank the participating children, adolescents and their parents as well as staff members from the outpatient department of our hospital.

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being
SDG 10 Reduced Inequalities

Research Areas and Centers

Academic Focus: Center for Brain, Behavior and Metabolism (CBBM)

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10.1007/s00431-005-1681-4

Cite this

@article{8a30c805ebd848f4a67011ae444c7ad2,

title = "Age, metabolic control and type of insulin regime influences health-related quality of life in children and adolescents with type 1 diabetes mellitus",

abstract = "The effects of illness and treatment of diabetes mellitus extend beyond medical outcomes. We therefore evaluated health-related quality of life (HRQOL) in children (aged 8-12 years) and adolescents (aged 13-16 years) with type 1 diabetes to compare their results with healthy peers and to identify HRQOL determinants. A total of 68 children and adolescents from a tertiary care clinic which specialises in the management of diabetes, completed the generic KINDL-R questionnaire. This instrument for children and adolescents has six dimensions and an additional module assessing condition-related HRQOL. Overall, the HRQOL was not different between patients with type 1 diabetes and healthy controls. In some areas, children and adolescents with diabetes reported a better HRQOL compared to healthy peers: adolescents reported better psychological well-being ( P <0.05) and children higher levels of well-being in the school domain ( P <0.05). In general, children reported a better HRQOL ( P <0.05) than adolescents with type 1 diabetes confirming age-related differences in HRQOL in the general population. Lower HbA1c (<8\%) and intensified insulin therapy (>3 injections/day) were associated with a better HRQOL in different domains ( P <0.05). The subscale {"}chronic illness{"} showed a better HRQOL ( P <0.001) in children and adolescents with diabetes compared to age-matched controls with other chronic conditions. Conclusion:Children and adolescents from a paediatric department specialising in diabetes management report good health-related quality of life. Younger age, good metabolic control and intensified insulin therapy are associated with a better health-related quality of life. Dimensions of health-related quality of life appear to play different roles at different ages, emphasising the importance of the multidimensional health-related quality of life concept and the value of age-appropriate self-reports.",

author = "Wagner, \{Verena M.\} and Esther M{\"u}ller–Godeffroy and \{Von Sengbusch\}, Simone and Stefan H{\"a}ger and Ute Thyen",

note = "Funding Information: Acknowledgements This study was supported by grants from the Association for Support of Rehabilitation Research LVA Schle-swig-Holstein-vffr, Germany (Verein zur F{\"o}rderung der Rehabili-tationsforschung). We would like to thank the participating children, adolescents and their parents as well as staff members from the outpatient department of our hospital. Copyright: Copyright 2019 Elsevier B.V., All rights reserved.",

year = "2005",

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doi = "10.1007/s00431-005-1681-4",

language = "English",

volume = "164",

pages = "491--496",

journal = "European Journal of Pediatrics",

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Age, metabolic control and type of insulin regime influences health-related quality of life in children and adolescents with type 1 diabetes mellitus. / Wagner, Verena M.; Müller–Godeffroy, Esther; Von Sengbusch, Simone et al.
In: European Journal of Pediatrics, Vol. 164, No. 8, 07.2005, p. 491-496.

Research output: Journal Articles › Journal articles › Research › peer-review

TY - JOUR

T1 - Age, metabolic control and type of insulin regime influences health-related quality of life in children and adolescents with type 1 diabetes mellitus

AU - Wagner, Verena M.

AU - Müller–Godeffroy, Esther

AU - Von Sengbusch, Simone

AU - Häger, Stefan

AU - Thyen, Ute

N1 - Funding Information: Acknowledgements This study was supported by grants from the Association for Support of Rehabilitation Research LVA Schle-swig-Holstein-vffr, Germany (Verein zur Förderung der Rehabili-tationsforschung). We would like to thank the participating children, adolescents and their parents as well as staff members from the outpatient department of our hospital. Copyright: Copyright 2019 Elsevier B.V., All rights reserved.

PY - 2005/7

Y1 - 2005/7

N2 - The effects of illness and treatment of diabetes mellitus extend beyond medical outcomes. We therefore evaluated health-related quality of life (HRQOL) in children (aged 8-12 years) and adolescents (aged 13-16 years) with type 1 diabetes to compare their results with healthy peers and to identify HRQOL determinants. A total of 68 children and adolescents from a tertiary care clinic which specialises in the management of diabetes, completed the generic KINDL-R questionnaire. This instrument for children and adolescents has six dimensions and an additional module assessing condition-related HRQOL. Overall, the HRQOL was not different between patients with type 1 diabetes and healthy controls. In some areas, children and adolescents with diabetes reported a better HRQOL compared to healthy peers: adolescents reported better psychological well-being ( P <0.05) and children higher levels of well-being in the school domain ( P <0.05). In general, children reported a better HRQOL ( P <0.05) than adolescents with type 1 diabetes confirming age-related differences in HRQOL in the general population. Lower HbA1c (<8%) and intensified insulin therapy (>3 injections/day) were associated with a better HRQOL in different domains ( P <0.05). The subscale "chronic illness" showed a better HRQOL ( P <0.001) in children and adolescents with diabetes compared to age-matched controls with other chronic conditions. Conclusion:Children and adolescents from a paediatric department specialising in diabetes management report good health-related quality of life. Younger age, good metabolic control and intensified insulin therapy are associated with a better health-related quality of life. Dimensions of health-related quality of life appear to play different roles at different ages, emphasising the importance of the multidimensional health-related quality of life concept and the value of age-appropriate self-reports.

AB - The effects of illness and treatment of diabetes mellitus extend beyond medical outcomes. We therefore evaluated health-related quality of life (HRQOL) in children (aged 8-12 years) and adolescents (aged 13-16 years) with type 1 diabetes to compare their results with healthy peers and to identify HRQOL determinants. A total of 68 children and adolescents from a tertiary care clinic which specialises in the management of diabetes, completed the generic KINDL-R questionnaire. This instrument for children and adolescents has six dimensions and an additional module assessing condition-related HRQOL. Overall, the HRQOL was not different between patients with type 1 diabetes and healthy controls. In some areas, children and adolescents with diabetes reported a better HRQOL compared to healthy peers: adolescents reported better psychological well-being ( P <0.05) and children higher levels of well-being in the school domain ( P <0.05). In general, children reported a better HRQOL ( P <0.05) than adolescents with type 1 diabetes confirming age-related differences in HRQOL in the general population. Lower HbA1c (<8%) and intensified insulin therapy (>3 injections/day) were associated with a better HRQOL in different domains ( P <0.05). The subscale "chronic illness" showed a better HRQOL ( P <0.001) in children and adolescents with diabetes compared to age-matched controls with other chronic conditions. Conclusion:Children and adolescents from a paediatric department specialising in diabetes management report good health-related quality of life. Younger age, good metabolic control and intensified insulin therapy are associated with a better health-related quality of life. Dimensions of health-related quality of life appear to play different roles at different ages, emphasising the importance of the multidimensional health-related quality of life concept and the value of age-appropriate self-reports.

UR - https://www.scopus.com/pages/publications/23044442683

U2 - 10.1007/s00431-005-1681-4

DO - 10.1007/s00431-005-1681-4

M3 - Journal articles

C2 - 15875213

AN - SCOPUS:23044442683

SN - 0340-6199

VL - 164

SP - 491

EP - 496

JO - European Journal of Pediatrics

JF - European Journal of Pediatrics

IS - 8

ER -

Age, metabolic control and type of insulin regime influences health-related quality of life in children and adolescents with type 1 diabetes mellitus

Abstract

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