Objectives: We aimed to evaluate the factors influencing true adult height (HT) after long-term (from 1987 to 2000) GH treatment in Design: Out of 347 near-adult (> 16 years) patients from 96 German centres, whose longitudinal growth was documented within KIGS (Pharmacia International Growth Database), 188 (45, × = 59%; bone age > 15 years) were available for further anthropometric measurements. Results: At a median GH dose of 0.88 (10th/90th percentiles: 0.47/1.06) IU/kg per week, a gain of 6.0 (- 1.3/+13) can above the projected adult height was recorded. Variables were recorded at GH start, after 1 year GH, puberty onset, and last visit on GH therapy. At these visits, the median ages were 11.7, 12.7, 14.2, 16.6 and 18.7 years; and median heights, 0.4, 1.1, 1.7, 1.7 and 1.3 SDS (UTS) respectively. Height gain (ΔHT) after GH discontinuation was 1.5 cm. Total ΔHT correlated (P < 0.001) negatively with bone age and HT SDS at GH start, but positively with ΔHT after the first year, ΔHT at puberty onset, and GH duration. Final HT correlated (P < 0.001) positively with HT at GH start, first-year ΔHT, and HT at puberty onset. Body mass index increased slightly (P < 0.05), with values at start and adult follow-up correlating highly (R = 0.70, P < 0.001). No major side effects of GH occurred. Conclusions: GH dosages conceived in the 1980s are safe but too low for most UTS patients. HT gain and height we determined by age and HT at GH start. Height gain during the first year on GH is indicative of overall height gain. After spontaneous or induced puberty, little gain in height occurs.
Research Areas and Centers
- Academic Focus: Center for Brain, Behavior and Metabolism (CBBM)