Adrenocorticotropin widens the focus of attention in humans. A nonlinear electroencephalographic analysis

Matthias Mölle*, Caroline Albrecht, Lisa Marshall, Horst L. Fehm, Jan Born

*Corresponding author for this work
20 Citations (Scopus)


Objective: This study examined the effects of ACTH 4-10, a fragment of adrenocorticotropin (ACTH) with known central nervous system (CNS) activity, on the dimensional complexity of the ongoing electroencephalographic (EEG) activity. Stressful stimuli cause ACTH to be released from the pituitary, and as a neuropeptide ACTH may concurrently exert adaptive influences on the brain's processing of these stimuli. Previous studies have indicated an impairing influence of ACTH on selective attention. Methods: Dimensional complexity of the EEG, which indexes the brain's way of stimulus processing, was evaluated while subjects performed tasks with different attention demands. Sixteen healthy men (23 to 33 years) were tested once after placebo and another time after administration of ACTH 4-10 (1.25 mg intravenously (IV), 30 minutes before testing). The EEG was recorded while subjects were presented with a dichotic listening task (consisting of the concurrent presentation of tone pips to the left and right ear). Subjects either a) listened to pips in both ears (divided attention), or b) listened selectively to pips in one ear (selective attention), or c) ignored all pips. Results: Dimensional complexity of the EEG was higher during divided than selective attention. ACTH significantly increased the EEG complexity during selective attention, in particular over the midfrontal cortex (F(z), C(z)). Conclusions: The effects support the view of a defocusing action of ACTH during selective attention that could serve to improve the organism's adaptation to stress stimuli.

Original languageEnglish
JournalPsychosomatic Medicine
Issue number5
Pages (from-to)497-502
Number of pages6
Publication statusPublished - 1997


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