Adjuvante therapie des mammakarzinoms - Bericht über die 10. Internationale Expertenkonsensuskonferenz St. Gallen 2007: "Care despite controversies"

Translated title of the contribution: Adjuvant therapy for breast cancer - Report on the 10th International Expert Consensus Conference in St. Gallen 2007: "Care despite controversies"

A. Rody, Manfred Kaufmann*

*Corresponding author for this work

    Abstract

    Treatment recommendations for operable breast cancer as determined in St. Gallen every two years are the only guidelines in the world concluded by an international panel of experts. Even if discrepancies exist due to the different backgrounds of the experts, several cornerstones for treatment decisions have become apparent. The risk classification of breast cancer is still based on the recommendations of the St. Gallen meeting 2005. HER-2 has changed from being a risk marker to a therapeutic target. The use of trastuzumab is now a new standard in adjuvant treatment settings. The evaluation of breast cancers according to their endocrine responsiveness and non-responsiveness is decisive for determining the decision for treatment. Hormonal treatment should be mandatory for all breast cancers which have an endocrine responsiveness or are at least potentially responsive and should include the risk-adapted use of an aromatase inhibitor for postmenopausal women. Tamoxifen is still a standard treatment for pre- and perimenopausal women. The additional use of a GnRH-analogue should be considered, depending on the individual risk assessment. The importance of anthracyclines and taxanes for adjuvant chemotherapy remains unchallenged. The molecular knowledge of prognostic and predictive markers is increasing and appropriate molecular test systems are currently being evaluated in large phase III trials. Thus, in the near future we can expect a more appropriate evaluation of the benefits of adjuvant therapy combined with an individual risk assessment.

    Translated title of the contributionAdjuvant therapy for breast cancer - Report on the 10th International Expert Consensus Conference in St. Gallen 2007: "Care despite controversies"
    Original languageGerman
    JournalGeburtshilfe und Frauenheilkunde
    Volume67
    Issue number5
    Pages (from-to)460-467
    Number of pages8
    ISSN0016-5751
    DOIs
    Publication statusPublished - 05.2007

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