Abstract
The physiology of adipose tissue has a key role in the pathogenesis of the metabolic syndrome and related cardiovascular disorders. Three main functions of adipocytes have been proposed to explain this role: the secretion of adipocyte-derived hormones (so-called adipokines), energy dissipation/ thermogenesis, and energy storage. There is mounting evidence that this repertoire of actions and reactions contributes to whole-body glucose and energy homeostasis, the control of blood pressure, immune-system function, haemostasis and atherosclerosis. In this article we highlight the most recent examples of adipocyte-based therapies and discuss future pharmacological options for exploiting this triad of adipocyte functions.
| Original language | English |
|---|---|
| Journal | Trends in Endocrinology and Metabolism |
| Volume | 17 |
| Issue number | 1 |
| Pages (from-to) | 26-32 |
| Number of pages | 7 |
| ISSN | 1043-2760 |
| DOIs | |
| Publication status | Published - 01.01.2006 |
Funding
J.K. is a Feodor-Lynen fellow of the Alexander von Humboldt Foundation. This work was supported by the Deutsche Forschungsgemeinschaft. AdipoR: adiponectin receptor aP2: fatty acid binding protein AMPK: AMP-activated protein kinase AR: angiotensin receptor ATGL: adipose triglyceride lipase CNTF: ciliary neurotrophic factor EC: endocannabinoid FATP: fatty acid transporter protein GIP: glucose-dependent insulinotropic polypeptide 11β-HSD-1: 11β-hydroxy steroid dehydrogenase-1 HSL: hormone sensitive lipase IL-6: Interleukin-6 IRS: insulin receptor substrate-1 PGC1α: PPARγ coactivator 1 α PPAR: peroxisome proliferator-activated receptor PAI-1: plasminogen activator inhibitor-1 RAS: renin angiotensin system RBP4: retinol-binding protein 4 RXRα: retinoid X receptor α SRC1: steroid receptor coactivator 1 SRM: steroid receptor modulator TNF-α: tumour necrosis factor α TZDs: thiazolidinediones TIF2: transcription intermediary factor 2
