Adipose tissue as source and target for novel therapies

Johannes Klein*, Nina Perwitz, Daniel Kraus, Mathias Fasshauer

*Corresponding author for this work
45 Citations (Scopus)


The physiology of adipose tissue has a key role in the pathogenesis of the metabolic syndrome and related cardiovascular disorders. Three main functions of adipocytes have been proposed to explain this role: the secretion of adipocyte-derived hormones (so-called adipokines), energy dissipation/ thermogenesis, and energy storage. There is mounting evidence that this repertoire of actions and reactions contributes to whole-body glucose and energy homeostasis, the control of blood pressure, immune-system function, haemostasis and atherosclerosis. In this article we highlight the most recent examples of adipocyte-based therapies and discuss future pharmacological options for exploiting this triad of adipocyte functions.

Original languageEnglish
JournalTrends in Endocrinology and Metabolism
Issue number1
Pages (from-to)26-32
Number of pages7
Publication statusPublished - 01.01.2006


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