Adenoviral E1A protein nuclear import is preferentially mediated by importin α3 in vitro

M. Köhler; D. Görlich; E. Hartmann; J. Franke

doi:10.1006/viro.2001.1151

Adenoviral E1A protein nuclear import is preferentially mediated by importin α3 in vitro

M. Köhler^*, D. Görlich, E. Hartmann, J. Franke

^*Corresponding author for this work

Institute of Biology

36 Citations (Scopus)

Abstract

Nuclear import of some viral proteins depends on importin α proteins. However, no preferences of distinct α-importins for any viral protein import have been demonstrated. We used in vitro import assays and observed that all ubiquitously expressed human importin α isoforms mediate nuclear translocation of adenoviral E1A. Competition with nucleoplasmin suggests that importin α3 is the most efficient import mediator of E1A.

Original language	English
Journal	Virology
Volume	289
Issue number	2
Pages (from-to)	186-191
Number of pages	6
ISSN	0042-6822
DOIs	https://doi.org/10.1006/viro.2001.1151
Publication status	Published - 25.10.2001

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10.1006/viro.2001.1151

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title = "Adenoviral E1A protein nuclear import is preferentially mediated by importin α3 in vitro",

abstract = "Nuclear import of some viral proteins depends on importin α proteins. However, no preferences of distinct α-importins for any viral protein import have been demonstrated. We used in vitro import assays and observed that all ubiquitously expressed human importin α isoforms mediate nuclear translocation of adenoviral E1A. Competition with nucleoplasmin suggests that importin α3 is the most efficient import mediator of E1A.",

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T1 - Adenoviral E1A protein nuclear import is preferentially mediated by importin α3 in vitro

AU - Köhler, M.

AU - Görlich, D.

AU - Hartmann, E.

AU - Franke, J.

PY - 2001/10/25

Y1 - 2001/10/25

N2 - Nuclear import of some viral proteins depends on importin α proteins. However, no preferences of distinct α-importins for any viral protein import have been demonstrated. We used in vitro import assays and observed that all ubiquitously expressed human importin α isoforms mediate nuclear translocation of adenoviral E1A. Competition with nucleoplasmin suggests that importin α3 is the most efficient import mediator of E1A.

AB - Nuclear import of some viral proteins depends on importin α proteins. However, no preferences of distinct α-importins for any viral protein import have been demonstrated. We used in vitro import assays and observed that all ubiquitously expressed human importin α isoforms mediate nuclear translocation of adenoviral E1A. Competition with nucleoplasmin suggests that importin α3 is the most efficient import mediator of E1A.

UR - https://www.scopus.com/pages/publications/0035950613

U2 - 10.1006/viro.2001.1151

DO - 10.1006/viro.2001.1151

M3 - Journal articles

AN - SCOPUS:0035950613

SN - 0042-6822

VL - 289

SP - 186

EP - 191

JO - Virology

JF - Virology

IS - 2

ER -

Adenoviral E1A protein nuclear import is preferentially mediated by importin α3 in vitro

Abstract

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