Abstract
Nuclear import of some viral proteins depends on importin α proteins. However, no preferences of distinct α-importins for any viral protein import have been demonstrated. We used in vitro import assays and observed that all ubiquitously expressed human importin α isoforms mediate nuclear translocation of adenoviral E1A. Competition with nucleoplasmin suggests that importin α3 is the most efficient import mediator of E1A.
Original language | English |
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Journal | Virology |
Volume | 289 |
Issue number | 2 |
Pages (from-to) | 186-191 |
Number of pages | 6 |
ISSN | 0042-6822 |
DOIs | |
Publication status | Published - 25.10.2001 |