Adenoviral E1A protein nuclear import is preferentially mediated by importin α3 in vitro

M. Köhler*, D. Görlich, E. Hartmann, J. Franke

*Corresponding author for this work
29 Citations (Scopus)

Abstract

Nuclear import of some viral proteins depends on importin α proteins. However, no preferences of distinct α-importins for any viral protein import have been demonstrated. We used in vitro import assays and observed that all ubiquitously expressed human importin α isoforms mediate nuclear translocation of adenoviral E1A. Competition with nucleoplasmin suggests that importin α3 is the most efficient import mediator of E1A.

Original languageEnglish
JournalVirology
Volume289
Issue number2
Pages (from-to)186-191
Number of pages6
ISSN0042-6822
DOIs
Publication statusPublished - 25.10.2001

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