Activation of the tissue kallikrein-kinin system in stroke

Simone Wagner; Pamela Kalb; Martina Lukosava; Ulrich Hilgenfeldt; Markus Schwaninger

doi:10.1016/S0022-510X(02)00208-3

Activation of the tissue kallikrein-kinin system in stroke

Simone Wagner, Pamela Kalb, Martina Lukosava, Ulrich Hilgenfeldt, Markus Schwaninger^*

^*Corresponding author for this work

Institute of Experimental and Clinical Pharmacology and Toxicology

45 Citations (Scopus)

Abstract

Edema formation is a major problem in large ischemic infarcts, and the underlying breakdown of the blood-brain barrier is only incompletely understood. Here, we report that the tissue kallikrein-kinin system, which influences the permeability of the blood-brain barrier, is activated in stroke. In 22 patients with large infarcts in the territory of the middle cerebral artery, we found elevated plasma concentrations of the tissue kinin kallidin. The data suggest that further studies on a possible role of kinin receptor antagonists on edema after stroke are warranted.

Original language	English
Journal	Journal of the Neurological Sciences
Volume	202
Issue number	1-2
Pages (from-to)	75-76
Number of pages	2
ISSN	0022-510X
DOIs	https://doi.org/10.1016/S0022-510X(02)00208-3
Publication status	Published - 15.10.2002

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Research Areas and Centers

Academic Focus: Center for Brain, Behavior and Metabolism (CBBM)

Access to Document

10.1016/S0022-510X(02)00208-3

Cite this

@article{0f95c054126f4beb9f8f72cb055fe19b,

title = "Activation of the tissue kallikrein-kinin system in stroke",

abstract = "Edema formation is a major problem in large ischemic infarcts, and the underlying breakdown of the blood-brain barrier is only incompletely understood. Here, we report that the tissue kallikrein-kinin system, which influences the permeability of the blood-brain barrier, is activated in stroke. In 22 patients with large infarcts in the territory of the middle cerebral artery, we found elevated plasma concentrations of the tissue kinin kallidin. The data suggest that further studies on a possible role of kinin receptor antagonists on edema after stroke are warranted.",

author = "Simone Wagner and Pamela Kalb and Martina Lukosava and Ulrich Hilgenfeldt and Markus Schwaninger",

year = "2002",

month = oct,

day = "15",

doi = "10.1016/S0022-510X(02)00208-3",

language = "English",

volume = "202",

pages = "75--76",

journal = "Journal of the Neurological Sciences",

issn = "0022-510X",

publisher = "Elsevier B.V.",

number = "1-2",

}

TY - JOUR

T1 - Activation of the tissue kallikrein-kinin system in stroke

AU - Wagner, Simone

AU - Kalb, Pamela

AU - Lukosava, Martina

AU - Hilgenfeldt, Ulrich

AU - Schwaninger, Markus

PY - 2002/10/15

Y1 - 2002/10/15

N2 - Edema formation is a major problem in large ischemic infarcts, and the underlying breakdown of the blood-brain barrier is only incompletely understood. Here, we report that the tissue kallikrein-kinin system, which influences the permeability of the blood-brain barrier, is activated in stroke. In 22 patients with large infarcts in the territory of the middle cerebral artery, we found elevated plasma concentrations of the tissue kinin kallidin. The data suggest that further studies on a possible role of kinin receptor antagonists on edema after stroke are warranted.

AB - Edema formation is a major problem in large ischemic infarcts, and the underlying breakdown of the blood-brain barrier is only incompletely understood. Here, we report that the tissue kallikrein-kinin system, which influences the permeability of the blood-brain barrier, is activated in stroke. In 22 patients with large infarcts in the territory of the middle cerebral artery, we found elevated plasma concentrations of the tissue kinin kallidin. The data suggest that further studies on a possible role of kinin receptor antagonists on edema after stroke are warranted.

UR - https://www.scopus.com/pages/publications/0037110415

U2 - 10.1016/S0022-510X(02)00208-3

DO - 10.1016/S0022-510X(02)00208-3

M3 - Journal articles

C2 - 12220696

AN - SCOPUS:0037110415

SN - 0022-510X

VL - 202

SP - 75

EP - 76

JO - Journal of the Neurological Sciences

JF - Journal of the Neurological Sciences

IS - 1-2

ER -

Activation of the tissue kallikrein-kinin system in stroke

Abstract

UN SDGs

Research Areas and Centers

Access to Document

Other files and links

Fingerprint

Cite this