Abstract
Edema formation is a major problem in large ischemic infarcts, and the underlying breakdown of the blood-brain barrier is only incompletely understood. Here, we report that the tissue kallikrein-kinin system, which influences the permeability of the blood-brain barrier, is activated in stroke. In 22 patients with large infarcts in the territory of the middle cerebral artery, we found elevated plasma concentrations of the tissue kinin kallidin. The data suggest that further studies on a possible role of kinin receptor antagonists on edema after stroke are warranted.
Original language | English |
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Journal | Journal of the Neurological Sciences |
Volume | 202 |
Issue number | 1-2 |
Pages (from-to) | 75-76 |
Number of pages | 2 |
ISSN | 0022-510X |
DOIs | |
Publication status | Published - 15.10.2002 |
Research Areas and Centers
- Academic Focus: Center for Brain, Behavior and Metabolism (CBBM)