Activation of the tissue kallikrein-kinin system in stroke

Simone Wagner, Pamela Kalb, Martina Lukosava, Ulrich Hilgenfeldt, Markus Schwaninger*

*Corresponding author for this work
38 Citations (Scopus)


Edema formation is a major problem in large ischemic infarcts, and the underlying breakdown of the blood-brain barrier is only incompletely understood. Here, we report that the tissue kallikrein-kinin system, which influences the permeability of the blood-brain barrier, is activated in stroke. In 22 patients with large infarcts in the territory of the middle cerebral artery, we found elevated plasma concentrations of the tissue kinin kallidin. The data suggest that further studies on a possible role of kinin receptor antagonists on edema after stroke are warranted.

Original languageEnglish
JournalJournal of the Neurological Sciences
Issue number1-2
Pages (from-to)75-76
Number of pages2
Publication statusPublished - 15.10.2002

Research Areas and Centers

  • Academic Focus: Center for Brain, Behavior and Metabolism (CBBM)


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