Abstract
The huge RNA genome of SARS coronavirus comprises a number of open reading frames that code for a total of eight accessory proteins. Although none of these are essential for virus replication, some appear to have a role in virus pathogenesis. Notably, some SARS-CoV accessory proteins have been shown to modulate the interferon signaling pathways and the production of pro-inflammatory cytokines. The structural information on these proteins is also limited, with only two (p7a and p9b) having their structures determined by X-ray crystallography. This review makes an attempt to summarize the published knowledge on SARS-CoV accessory proteins, with an emphasis on their involvement in virus-host interaction. The accessory proteins of other coronaviruses are also briefly discussed. This paper forms part of a series of invited articles in Antiviral Research on "From SARS to MERS: 10 years of research on highly pathogenic human coronaviruses" (see Introduction by Hilgenfeld and Peiris (2013)).
| Original language | English |
|---|---|
| Journal | Antiviral Research |
| Volume | 109 |
| Issue number | 1 |
| Pages (from-to) | 97-109 |
| Number of pages | 13 |
| ISSN | 0166-3542 |
| DOIs | |
| Publication status | Published - 01.01.2014 |
Funding
This work was partially supported by a Competitive Research Programme (CRP) grant ( R-154-000-529-281 ), the National Research Foundation, Singapore , and an Academic Research Fund (AcRF) Tier 1 grant ( RGT17/13 ), Nanyang Technological University and Ministry of Education, Singapore.
Research Areas and Centers
- Academic Focus: Center for Infection and Inflammation Research (ZIEL)
Coronavirus related work
- Research on SARS-CoV-2 / COVID-19
