Abstract
B-cell functions were investigated in a well-defined high-risk group for the development of AIDS/AIDS-related complex (ARC). Stimulation of mononuclear cells (MNC) with T-cell-independent polyclonal B-cell activators failed to increase high spontaneous IgG levels observed in vivo and in vitro. The secretion of IgM following stimulation with Klebsiella M (Klebs M) or Salmonella (Salm) membrane preparation increased by a factor of 4 to 6 and thus ranged between the results of the control group and those of AIDS/ARC patients; the response to a T-cell-independent B-cell mitogen, Staphylococcus aureus Cowan I (SAC), showed profound abnormalities as well in this group. This indicates that functional B-cell abnormalities can be seen in addition to T-cell dysfunctions in patients at increased risk for the development of AIDS/ARC.
| Original language | English |
|---|---|
| Journal | Diagnostic Immunology |
| Volume | 4 |
| Issue number | 2 |
| Pages (from-to) | 107-111 |
| Number of pages | 5 |
| ISSN | 0735-3111 |
| Publication status | Published - 1986 |
Research Areas and Centers
- Academic Focus: Center for Infection and Inflammation Research (ZIEL)
