A Spectrometer for Magnetic Particle Imaging

S. Biederer, T. Sattel, T. Knopp, K. Lüdtke-Buzug, B. Gleich, J. Weizenecker, J. Borgert, T. M. Buzug


Recently, a new tomographic imaging technique called magnetic particle imaging was proposed. It allows for the high resolution measurement of the spatial distribution of magnetic nanoparticles. The method is based on the non-linear response of magnetic nanoparticles (e.g. superparamagnetic iron oxide particles, SPIOs). In this work, a spectrometer is presented that allows for the analysis of the nanoparticle quality used in the imaging process. The number of useable harmonics in the non-linear particle response strongly depends on the diameter of the SPIOs. We have found that different lots do not perform equally. Therefore, improvements of the magnetic nanoparticles are desired. Since the instrument directly measures the non-linear characteristics of the nanoparticles, related properties for magnetic particle imaging can be achieved as well. This especially assists the chemical nanoparticle preparation process. An optimized coil setup to measure the particle response is described. Moreover, a series of measurements have been carried out to evaluate the spectral results using different field parameters and particle concentrations of commercially available MRI-approved SPIOs. Furthermore, the measurements are compared to simulations based on the Langivin theory of paramagnetism.

Original languageEnglish
Title of host publication4th European Conference of the International Federation for Medical and Biological Engineering
Number of pages4
PublisherSpringer Berlin Heidelberg
Publication date01.12.2008
ISBN (Print)978-3-540-89207-6
ISBN (Electronic)978-3-540-89208-3
Publication statusPublished - 01.12.2008
Event4th European Conference of the International Federation for Medical and Biological Engineering - Antwerp, Belgium
Duration: 23.11.200827.11.2008
Conference number: 81647


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