A single application of cold atmospheric plasma (CAP) improves blood flow parameters in chronic wounds

Sophie Schleusser; Lysann Schulz; Jungin Song; Henriette Deichmann; Anna Catharina Griesmann; Felix H. Stang; Peter Mailaender; Robert Kraemer; Markus Kleemann; Tobias Kisch

doi:10.1111/micc.12754

A single application of cold atmospheric plasma (CAP) improves blood flow parameters in chronic wounds

Sophie Schleusser^*, Lysann Schulz, Jungin Song, Henriette Deichmann, Anna Catharina Griesmann, Felix H. Stang, Peter Mailaender, Robert Kraemer, Markus Kleemann, Tobias Kisch

^*Corresponding author for this work

13 Citations (Scopus)

Abstract

Objective: To find out whether application of cold atmospheric plasma (CAP) affects microcirculation in chronic wounds. Methods: We treated 20 patients with chronic wounds on the lower extremity with CAP. Blood flow parameters of wounds were assessed with combined Laser-Doppler-Flowmetry and spectrophotometry in tissue depth of 2 and 6–8 mm. Parameters were assessed under standardized conditions before and over the course of 30 min after application of CAP. Results: Deep capillary blood flow increased significantly by up to 24.33% (percentage change) after treatment with CAP and remained significantly elevated until the end of measuring period at 30 min. Superficial oxygen tissue saturation was significantly elevated by 14.05% for the first 5 min after treatment. Postcapillary venous filling pressure was significantly elevated by 10.23% 19 min after CAP and stayed significantly elevated starting from minute 24 until the end of measuring. Conclusion: Cold atmospheric plasma increases microcirculation parameters in chronic wounds significantly. As CAP is known for its benefits in wound healing, the effects observed may explain the improved healing of chronic wounds after its use. Whether CAP-application can increase blood flow in chronic wounds for longer periods of time or boosts blood flow when applied more than once should be subject to further research.

Original language	English
Article number	e12754
Journal	Microcirculation
Volume	29
Issue number	3
ISSN	1073-9688
DOIs	https://doi.org/10.1111/micc.12754
Publication status	Published - 04.2022

Funding

This study was funded by the University of Lübeck. This work was not funded by National Institute of Health (NIH), Wellcome Trust, Howard Hughes Medical Institute (HHMI) or other institutes. The PlasmaDerm device was provided by Cinogy GmbH, Germany. No financial or other support was given by the above‐mentioned company ® This study was funded by the University of L?beck. This work was not funded by National Institute of Health (NIH), Wellcome Trust, Howard Hughes Medical Institute (HHMI) or other institutes. The PlasmaDerm? device was provided by Cinogy GmbH, Germany. No financial or other support was given by the above-mentioned company The authors thank the Department of Vascular Surgery (University Hospital of Schleswig-Holstein, L?beck) for taking part in this clinical trial. Furthermore, we thank all wound care nurses for assistance and help with the patients. Open Access funding enabled and organized by Projekt DEAL.

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

DFG Research Classification Scheme

2.22-27 Orthopaedics, Traumatology, Reconstructive Surgery

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10.1111/micc.12754

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title = "A single application of cold atmospheric plasma (CAP) improves blood flow parameters in chronic wounds",

abstract = "Objective: To find out whether application of cold atmospheric plasma (CAP) affects microcirculation in chronic wounds. Methods: We treated 20 patients with chronic wounds on the lower extremity with CAP. Blood flow parameters of wounds were assessed with combined Laser-Doppler-Flowmetry and spectrophotometry in tissue depth of 2 and 6–8 mm. Parameters were assessed under standardized conditions before and over the course of 30 min after application of CAP. Results: Deep capillary blood flow increased significantly by up to 24.33\% (percentage change) after treatment with CAP and remained significantly elevated until the end of measuring period at 30 min. Superficial oxygen tissue saturation was significantly elevated by 14.05\% for the first 5 min after treatment. Postcapillary venous filling pressure was significantly elevated by 10.23\% 19 min after CAP and stayed significantly elevated starting from minute 24 until the end of measuring. Conclusion: Cold atmospheric plasma increases microcirculation parameters in chronic wounds significantly. As CAP is known for its benefits in wound healing, the effects observed may explain the improved healing of chronic wounds after its use. Whether CAP-application can increase blood flow in chronic wounds for longer periods of time or boosts blood flow when applied more than once should be subject to further research.",

author = "Sophie Schleusser and Lysann Schulz and Jungin Song and Henriette Deichmann and Griesmann, \{Anna Catharina\} and Stang, \{Felix H.\} and Peter Mailaender and Robert Kraemer and Markus Kleemann and Tobias Kisch",

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doi = "10.1111/micc.12754",

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AU - Schleusser, Sophie

AU - Schulz, Lysann

AU - Song, Jungin

AU - Deichmann, Henriette

AU - Griesmann, Anna Catharina

AU - Stang, Felix H.

AU - Mailaender, Peter

AU - Kraemer, Robert

AU - Kleemann, Markus

AU - Kisch, Tobias

PY - 2022/4

Y1 - 2022/4

N2 - Objective: To find out whether application of cold atmospheric plasma (CAP) affects microcirculation in chronic wounds. Methods: We treated 20 patients with chronic wounds on the lower extremity with CAP. Blood flow parameters of wounds were assessed with combined Laser-Doppler-Flowmetry and spectrophotometry in tissue depth of 2 and 6–8 mm. Parameters were assessed under standardized conditions before and over the course of 30 min after application of CAP. Results: Deep capillary blood flow increased significantly by up to 24.33% (percentage change) after treatment with CAP and remained significantly elevated until the end of measuring period at 30 min. Superficial oxygen tissue saturation was significantly elevated by 14.05% for the first 5 min after treatment. Postcapillary venous filling pressure was significantly elevated by 10.23% 19 min after CAP and stayed significantly elevated starting from minute 24 until the end of measuring. Conclusion: Cold atmospheric plasma increases microcirculation parameters in chronic wounds significantly. As CAP is known for its benefits in wound healing, the effects observed may explain the improved healing of chronic wounds after its use. Whether CAP-application can increase blood flow in chronic wounds for longer periods of time or boosts blood flow when applied more than once should be subject to further research.

AB - Objective: To find out whether application of cold atmospheric plasma (CAP) affects microcirculation in chronic wounds. Methods: We treated 20 patients with chronic wounds on the lower extremity with CAP. Blood flow parameters of wounds were assessed with combined Laser-Doppler-Flowmetry and spectrophotometry in tissue depth of 2 and 6–8 mm. Parameters were assessed under standardized conditions before and over the course of 30 min after application of CAP. Results: Deep capillary blood flow increased significantly by up to 24.33% (percentage change) after treatment with CAP and remained significantly elevated until the end of measuring period at 30 min. Superficial oxygen tissue saturation was significantly elevated by 14.05% for the first 5 min after treatment. Postcapillary venous filling pressure was significantly elevated by 10.23% 19 min after CAP and stayed significantly elevated starting from minute 24 until the end of measuring. Conclusion: Cold atmospheric plasma increases microcirculation parameters in chronic wounds significantly. As CAP is known for its benefits in wound healing, the effects observed may explain the improved healing of chronic wounds after its use. Whether CAP-application can increase blood flow in chronic wounds for longer periods of time or boosts blood flow when applied more than once should be subject to further research.

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A single application of cold atmospheric plasma (CAP) improves blood flow parameters in chronic wounds

Abstract

Funding

UN SDGs

DFG Research Classification Scheme

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