A simple clinical instrument to predict the survival probability of breast cancer patients receiving radiotherapy for bone metastases

Stefan Janssen, Rapha Haus, Steven E. Schild, Dirk Rades*

*Corresponding author for this work

Abstract

Background/Aim: Individualization of treatment may improve the outcome of patients with bone metastases from breast cancer. To support physicians when selecting individualized programs for these patients, a simple instrument for predicting survival was created. Patients and Methods: In 126 female patients with breast cancer irradiated for bone metastases, 11 characteristics were evaluated with respect to survival. Results: On Cox regression analysis, Eastern Cooperative Oncology Group performance score (0-1 vs. ≥2; p=0.032) and visceral metastases (absence vs. presence; p=0.017) were independently associated with survival and incorporated into the scoring instrument. Three prognostic groups (0, 1 or 2 points) were designated with 12-month survival rates of 38%, 57% and 91%, and 24-month survival rates of 32%, 36% and 80%, respectively (p<0.001). Conclusion: This easy-to-use scoring instrument allows physicians to estimate the lifespan of patients irradiated for bone metastases from breast cancer and can facilitate individualization of their treatment.

Original languageEnglish
JournalAnticancer Research
Volume40
Issue number1
Pages (from-to)367-371
Number of pages5
ISSN0250-7005
DOIs
Publication statusPublished - 2020

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