A Sensor for the Non-invasive Determination of Hemoglobin in Sampling Tubes

A. Opp; U. G. Hofmann; S. Boye; L. Dibbelt; H. Gehring

doi:10.1007/978-3-642-03885-3_164

A Sensor for the Non-invasive Determination of Hemoglobin in Sampling Tubes

A. Opp, U. G. Hofmann, S. Boye, L. Dibbelt, H. Gehring

Abstract

Continuous, online and non-invasive monitoring of critical blood parameters such as the concentration of hemoglobin (ctHb) is of great value for clinical applications. The absorption spectrum of hemoglobin, of its derivatives as well as of its plasma dominates the optical properties of whole blood in the visible and infrared bands. In the present work a novel sensor is introduced that uses two wavelengths in the infrared range of the electromagnetic spectrum to determine the concentration of hemoglobin in whole blood. The described device can be used to measure ctHb of blood in sampling tubes, used for drainage systems or during a blood donation session. To avoid interference with the oxygenation status of the blood the measurement wavelength is selected at isosbestic points. Measurements are compared to an invasive reference method. The described set-up allows for detecting hemoglobin concentrations ranging up to 16.5 g/dL. Since light is subjected to scattering when traveling through whole blood, resulting in a bias, the sensor is calibrated empirically. In the present study tubes from three different manufacturers are used. Within the above mentioned range the sensor exhibits an accuracy (ARMS, root-mean-square difference between measured values and reference values) of 0.84.

Original language	English
Title of host publication	World Congress on Medical Physics and Biomedical Engineering, September 7 - 12, 2009, Munich, Germany
Editors	Olaf Dössel, Wolfgang C. Schlegel
Number of pages	3
Volume	25/7
Place of Publication	Berlin, Heidelberg
Publisher	Springer Berlin Heidelberg
Publication date	01.09.2009
Pages	590-592
ISBN (Print)	978-3-642-03884-6
ISBN (Electronic)	978-3-642-03885-3
DOIs	https://doi.org/10.1007/978-3-642-03885-3_164
Publication status	Published - 01.09.2009
Event	World Congress on Medical Physics and Biomedical Engineering: Diagnostic Imaging - Munich , Germany Duration: 07.09.2009 → 12.09.2009 Conference number: 81644

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Opp, A., Hofmann, U. G., Boye, S., Dibbelt, L., & Gehring, H. (2009). A Sensor for the Non-invasive Determination of Hemoglobin in Sampling Tubes. In O. Dössel, & W. C. Schlegel (Eds.), World Congress on Medical Physics and Biomedical Engineering, September 7 - 12, 2009, Munich, Germany (Vol. 25/7, pp. 590-592). (IFMBE Proceedings; Vol. 25/7). Springer Berlin Heidelberg. https://doi.org/10.1007/978-3-642-03885-3_164

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abstract = "Continuous, online and non-invasive monitoring of critical blood parameters such as the concentration of hemoglobin (ctHb) is of great value for clinical applications. The absorption spectrum of hemoglobin, of its derivatives as well as of its plasma dominates the optical properties of whole blood in the visible and infrared bands. In the present work a novel sensor is introduced that uses two wavelengths in the infrared range of the electromagnetic spectrum to determine the concentration of hemoglobin in whole blood. The described device can be used to measure ctHb of blood in sampling tubes, used for drainage systems or during a blood donation session. To avoid interference with the oxygenation status of the blood the measurement wavelength is selected at isosbestic points. Measurements are compared to an invasive reference method. The described set-up allows for detecting hemoglobin concentrations ranging up to 16.5 g/dL. Since light is subjected to scattering when traveling through whole blood, resulting in a bias, the sensor is calibrated empirically. In the present study tubes from three different manufacturers are used. Within the above mentioned range the sensor exhibits an accuracy (ARMS, root-mean-square difference between measured values and reference values) of 0.84.",

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Opp, A, Hofmann, UG, Boye, S, Dibbelt, L & Gehring, H 2009, A Sensor for the Non-invasive Determination of Hemoglobin in Sampling Tubes. in O Dössel & WC Schlegel (eds), World Congress on Medical Physics and Biomedical Engineering, September 7 - 12, 2009, Munich, Germany. vol. 25/7, IFMBE Proceedings, vol. 25/7, Springer Berlin Heidelberg, Berlin, Heidelberg, pp. 590-592, World Congress on Medical Physics and Biomedical Engineering: Diagnostic Imaging, Munich , Bavaria, Germany, 07.09.09. https://doi.org/10.1007/978-3-642-03885-3_164

A Sensor for the Non-invasive Determination of Hemoglobin in Sampling Tubes. / Opp, A.; Hofmann, U. G.; Boye, S. et al.
World Congress on Medical Physics and Biomedical Engineering, September 7 - 12, 2009, Munich, Germany. ed. / Olaf Dössel; Wolfgang C. Schlegel. Vol. 25/7 Berlin, Heidelberg: Springer Berlin Heidelberg, 2009. p. 590-592 (IFMBE Proceedings; Vol. 25/7).

Research output: Chapters in Books/Reports/Conference Proceedings › Conference contribution › peer-review

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AU - Hofmann, U. G.

AU - Boye, S.

AU - Dibbelt, L.

AU - Gehring, H.

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N2 - Continuous, online and non-invasive monitoring of critical blood parameters such as the concentration of hemoglobin (ctHb) is of great value for clinical applications. The absorption spectrum of hemoglobin, of its derivatives as well as of its plasma dominates the optical properties of whole blood in the visible and infrared bands. In the present work a novel sensor is introduced that uses two wavelengths in the infrared range of the electromagnetic spectrum to determine the concentration of hemoglobin in whole blood. The described device can be used to measure ctHb of blood in sampling tubes, used for drainage systems or during a blood donation session. To avoid interference with the oxygenation status of the blood the measurement wavelength is selected at isosbestic points. Measurements are compared to an invasive reference method. The described set-up allows for detecting hemoglobin concentrations ranging up to 16.5 g/dL. Since light is subjected to scattering when traveling through whole blood, resulting in a bias, the sensor is calibrated empirically. In the present study tubes from three different manufacturers are used. Within the above mentioned range the sensor exhibits an accuracy (ARMS, root-mean-square difference between measured values and reference values) of 0.84.

AB - Continuous, online and non-invasive monitoring of critical blood parameters such as the concentration of hemoglobin (ctHb) is of great value for clinical applications. The absorption spectrum of hemoglobin, of its derivatives as well as of its plasma dominates the optical properties of whole blood in the visible and infrared bands. In the present work a novel sensor is introduced that uses two wavelengths in the infrared range of the electromagnetic spectrum to determine the concentration of hemoglobin in whole blood. The described device can be used to measure ctHb of blood in sampling tubes, used for drainage systems or during a blood donation session. To avoid interference with the oxygenation status of the blood the measurement wavelength is selected at isosbestic points. Measurements are compared to an invasive reference method. The described set-up allows for detecting hemoglobin concentrations ranging up to 16.5 g/dL. Since light is subjected to scattering when traveling through whole blood, resulting in a bias, the sensor is calibrated empirically. In the present study tubes from three different manufacturers are used. Within the above mentioned range the sensor exhibits an accuracy (ARMS, root-mean-square difference between measured values and reference values) of 0.84.

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SN - 978-3-642-03884-6

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BT - World Congress on Medical Physics and Biomedical Engineering, September 7 - 12, 2009, Munich, Germany

A2 - Dössel, Olaf

A2 - Schlegel, Wolfgang C.

PB - Springer Berlin Heidelberg

CY - Berlin, Heidelberg

T2 - World Congress on Medical Physics and Biomedical Engineering: Diagnostic Imaging

Y2 - 7 September 2009 through 12 September 2009

ER -

Opp A, Hofmann UG, Boye S, Dibbelt L, Gehring H. A Sensor for the Non-invasive Determination of Hemoglobin in Sampling Tubes. In Dössel O, Schlegel WC, editors, World Congress on Medical Physics and Biomedical Engineering, September 7 - 12, 2009, Munich, Germany. Vol. 25/7. Berlin, Heidelberg: Springer Berlin Heidelberg. 2009. p. 590-592. (IFMBE Proceedings). doi: 10.1007/978-3-642-03885-3_164

A Sensor for the Non-invasive Determination of Hemoglobin in Sampling Tubes

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