A room temperature ionic liquid as convenient solvent for the oxidative folding of conopeptides

Alesia A Miloslavina; Enrico Leipold; Michael Kijas; Annegret Stark; Stefan H Heinemann; Diana Imhof

doi:10.1002/psc.1106

A room temperature ionic liquid as convenient solvent for the oxidative folding of conopeptides

Alesia A Miloslavina, Enrico Leipold, Michael Kijas, Annegret Stark, Stefan H Heinemann, Diana Imhof

Department of Anesthesiology and Intensive Care Medicine

Friedrich Schiller University Jena

30 Citations (Scopus)

Abstract

We report the first example of conopeptide oxidation performed in a biocompatible ionic liquid, 1-ethyl-3-methylimidazolium acetate ([C(2)mim][OAc]), which enables the efficient formation of both hydrophilic and poorly water-soluble conotoxins compared with conventional methods. Moreover, the method features a high-concentration approach ultimately leading to higher yields at reduced separation effort.

Original language	English
Journal	Journal of peptide science : an official publication of the European Peptide Society
Volume	15
Issue number	2
Pages (from-to)	72-7
Number of pages	6
ISSN	1075-2617
DOIs	https://doi.org/10.1002/psc.1106
Publication status	Published - 02.2009

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10.1002/psc.1106

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abstract = "We report the first example of conopeptide oxidation performed in a biocompatible ionic liquid, 1-ethyl-3-methylimidazolium acetate ([C(2)mim][OAc]), which enables the efficient formation of both hydrophilic and poorly water-soluble conotoxins compared with conventional methods. Moreover, the method features a high-concentration approach ultimately leading to higher yields at reduced separation effort.",

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AU - Heinemann, Stefan H

AU - Imhof, Diana

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AB - We report the first example of conopeptide oxidation performed in a biocompatible ionic liquid, 1-ethyl-3-methylimidazolium acetate ([C(2)mim][OAc]), which enables the efficient formation of both hydrophilic and poorly water-soluble conotoxins compared with conventional methods. Moreover, the method features a high-concentration approach ultimately leading to higher yields at reduced separation effort.

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M3 - Journal articles

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A room temperature ionic liquid as convenient solvent for the oxidative folding of conopeptides

Abstract

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