A room temperature ionic liquid as convenient solvent for the oxidative folding of conopeptides

Alesia A Miloslavina, Enrico Leipold, Michael Kijas, Annegret Stark, Stefan H Heinemann, Diana Imhof

Abstract

We report the first example of conopeptide oxidation performed in a biocompatible ionic liquid, 1-ethyl-3-methylimidazolium acetate ([C(2)mim][OAc]), which enables the efficient formation of both hydrophilic and poorly water-soluble conotoxins compared with conventional methods. Moreover, the method features a high-concentration approach ultimately leading to higher yields at reduced separation effort.

Original languageEnglish
JournalJournal of peptide science : an official publication of the European Peptide Society
Volume15
Issue number2
Pages (from-to)72-7
Number of pages6
ISSN1075-2617
DOIs
Publication statusPublished - 02.2009

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