Abstract
We report the first example of conopeptide oxidation performed in a biocompatible ionic liquid, 1-ethyl-3-methylimidazolium acetate ([C(2)mim][OAc]), which enables the efficient formation of both hydrophilic and poorly water-soluble conotoxins compared with conventional methods. Moreover, the method features a high-concentration approach ultimately leading to higher yields at reduced separation effort.
Original language | English |
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Journal | Journal of peptide science : an official publication of the European Peptide Society |
Volume | 15 |
Issue number | 2 |
Pages (from-to) | 72-7 |
Number of pages | 6 |
ISSN | 1075-2617 |
DOIs | |
Publication status | Published - 02.2009 |