A randomized trial (RAREST-01) comparing Mepitel® Film and standard care for prevention of radiation dermatitis in patients irradiated for locally advanced squamous cell carcinoma of the head-and-neck (SCCHN)

Dirk Rades; Carlos A. Narvaez; Laura Splettstößer; Claudia Dömer; Cornelia Setter; Christian Idel; Julika Ribbat-Idel; Sven Perner; Tobias Bartscht; Denise Olbrich; Steven E. Schild; Jesper Carl

doi:10.1016/j.radonc.2019.07.023

A randomized trial (RAREST-01) comparing Mepitel® Film and standard care for prevention of radiation dermatitis in patients irradiated for locally advanced squamous cell carcinoma of the head-and-neck (SCCHN)

Dirk Rades^*, Carlos A. Narvaez, Laura Splettstößer, Claudia Dömer, Cornelia Setter, Christian Idel, Julika Ribbat-Idel, Sven Perner, Tobias Bartscht, Denise Olbrich, Steven E. Schild, Jesper Carl

^*Corresponding author for this work

33 Citations (Scopus)

Abstract

Mepitel® Film (MEP) and standard care (STD) were compared for radiation dermatitis in SCCHN patients. This trial was stopped prematurely since13/28 patients did not tolerate MEP. Grade ≥2 dermatitis: 34.8% (MEP) vs. 35.7% (STD) at 50 Gy, 65.2% vs. 59.3% at 60 Gy. MEP was unsatisfactorily tolerated and appeared not superior (NCT03047174).

Original language	English
Journal	Radiotherapy and Oncology
Volume	139
Pages (from-to)	79-82
Number of pages	4
ISSN	0167-8140
DOIs	https://doi.org/10.1016/j.radonc.2019.07.023
Publication status	Published - 10.2019

Funding

As part of the project InnoCan, the RAREST-01 study was funded by the European Regional Development Fund through the Interreg Deutschland-Danmark program (reference: Innoc 11-1.0-15). The funding body has no role in the design of the study, in collection, analysis and interpretation of the data and in writing of the manuscript.

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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Rades, D., Narvaez, C. A., Splettstößer, L., Dömer, C., Setter, C., Idel, C., Ribbat-Idel, J., Perner, S., Bartscht, T., Olbrich, D., Schild, S. E., & Carl, J. (2019). A randomized trial (RAREST-01) comparing Mepitel® Film and standard care for prevention of radiation dermatitis in patients irradiated for locally advanced squamous cell carcinoma of the head-and-neck (SCCHN). Radiotherapy and Oncology, 139, 79-82. https://doi.org/10.1016/j.radonc.2019.07.023

@article{e0da01c130dc4791ba7ba9d800581a35,

title = "A randomized trial (RAREST-01) comparing Mepitel{\textregistered} Film and standard care for prevention of radiation dermatitis in patients irradiated for locally advanced squamous cell carcinoma of the head-and-neck (SCCHN)",

abstract = "Mepitel{\textregistered} Film (MEP) and standard care (STD) were compared for radiation dermatitis in SCCHN patients. This trial was stopped prematurely since13/28 patients did not tolerate MEP. Grade ≥2 dermatitis: 34.8\% (MEP) vs. 35.7\% (STD) at 50 Gy, 65.2\% vs. 59.3\% at 60 Gy. MEP was unsatisfactorily tolerated and appeared not superior (NCT03047174).",

author = "Dirk Rades and Narvaez, \{Carlos A.\} and Laura Splettst{\"o}{\ss}er and Claudia D{\"o}mer and Cornelia Setter and Christian Idel and Julika Ribbat-Idel and Sven Perner and Tobias Bartscht and Denise Olbrich and Schild, \{Steven E.\} and Jesper Carl",

year = "2019",

month = oct,

doi = "10.1016/j.radonc.2019.07.023",

language = "English",

volume = "139",

pages = "79--82",

journal = "Radiotherapy and Oncology",

issn = "0167-8140",

publisher = "Elsevier Ireland Ltd",

}

Rades, D , Narvaez, CA, Splettstößer, L, Dömer, C, Setter, C, Idel, C, Ribbat-Idel, J, Perner, S, Bartscht, T , Olbrich, D, Schild, SE & Carl, J 2019, 'A randomized trial (RAREST-01) comparing Mepitel® Film and standard care for prevention of radiation dermatitis in patients irradiated for locally advanced squamous cell carcinoma of the head-and-neck (SCCHN)', Radiotherapy and Oncology, vol. 139, pp. 79-82. https://doi.org/10.1016/j.radonc.2019.07.023

A randomized trial (RAREST-01) comparing Mepitel® Film and standard care for prevention of radiation dermatitis in patients irradiated for locally advanced squamous cell carcinoma of the head-and-neck (SCCHN). / Rades, Dirk ; Narvaez, Carlos A.; Splettstößer, Laura et al.
In: Radiotherapy and Oncology, Vol. 139, 10.2019, p. 79-82.

Research output: Journal Articles › Journal articles › Research › peer-review

TY - JOUR

T1 - A randomized trial (RAREST-01) comparing Mepitel® Film and standard care for prevention of radiation dermatitis in patients irradiated for locally advanced squamous cell carcinoma of the head-and-neck (SCCHN)

AU - Rades, Dirk

AU - Narvaez, Carlos A.

AU - Splettstößer, Laura

AU - Dömer, Claudia

AU - Setter, Cornelia

AU - Idel, Christian

AU - Ribbat-Idel, Julika

AU - Perner, Sven

AU - Bartscht, Tobias

AU - Olbrich, Denise

AU - Schild, Steven E.

AU - Carl, Jesper

PY - 2019/10

Y1 - 2019/10

N2 - Mepitel® Film (MEP) and standard care (STD) were compared for radiation dermatitis in SCCHN patients. This trial was stopped prematurely since13/28 patients did not tolerate MEP. Grade ≥2 dermatitis: 34.8% (MEP) vs. 35.7% (STD) at 50 Gy, 65.2% vs. 59.3% at 60 Gy. MEP was unsatisfactorily tolerated and appeared not superior (NCT03047174).

AB - Mepitel® Film (MEP) and standard care (STD) were compared for radiation dermatitis in SCCHN patients. This trial was stopped prematurely since13/28 patients did not tolerate MEP. Grade ≥2 dermatitis: 34.8% (MEP) vs. 35.7% (STD) at 50 Gy, 65.2% vs. 59.3% at 60 Gy. MEP was unsatisfactorily tolerated and appeared not superior (NCT03047174).

UR - https://www.scopus.com/pages/publications/85070690069

U2 - 10.1016/j.radonc.2019.07.023

DO - 10.1016/j.radonc.2019.07.023

M3 - Journal articles

C2 - 31431372

AN - SCOPUS:85070690069

SN - 0167-8140

VL - 139

SP - 79

EP - 82

JO - Radiotherapy and Oncology

JF - Radiotherapy and Oncology

ER -

A randomized trial (RAREST-01) comparing Mepitel® Film and standard care for prevention of radiation dermatitis in patients irradiated for locally advanced squamous cell carcinoma of the head-and-neck (SCCHN)

Abstract

Funding

UN SDGs

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