A protein of the endoplasmic reticulum involved early in polypeptide translocation

Dirk Görlich; Enno Hartmann; Siegfried Prehn; Tom A. Rapoport

A protein of the endoplasmic reticulum involved early in polypeptide translocation

Dirk Görlich, Enno Hartmann, Siegfried Prehn, Tom A. Rapoport^*

^*Corresponding author for this work

Institute of Biology

205 Citations (Scopus)

Abstract

To identify components of the mammalian endoplasmic reticulum involved in the translocation of secretory proteins, crosslinking and reconstitution methods were combined. A multispanning abundant membrane glycoprotein was found which is in proximity to nascent chains early in translocation. In reconstituted proteoliposomes, this protein is stimulatory or required for the translocation of secretory proteins.

Original language	English
Journal	Nature
Volume	357
Issue number	6373
Pages (from-to)	47-52
Number of pages	6
ISSN	0028-0836
Publication status	Published - 01.12.1992

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Cite this

@article{650e6a431b8c4ba99c505c43248573fd,

title = "A protein of the endoplasmic reticulum involved early in polypeptide translocation",

abstract = "To identify components of the mammalian endoplasmic reticulum involved in the translocation of secretory proteins, crosslinking and reconstitution methods were combined. A multispanning abundant membrane glycoprotein was found which is in proximity to nascent chains early in translocation. In reconstituted proteoliposomes, this protein is stimulatory or required for the translocation of secretory proteins.",

author = "Dirk G{\"o}rlich and Enno Hartmann and Siegfried Prehn and Rapoport, {Tom A.}",

year = "1992",

month = dec,

day = "1",

language = "English",

volume = "357",

pages = "47--52",

journal = "Nature",

issn = "0028-0836",

number = "6373",

}

TY - JOUR

T1 - A protein of the endoplasmic reticulum involved early in polypeptide translocation

AU - Görlich, Dirk

AU - Hartmann, Enno

AU - Prehn, Siegfried

AU - Rapoport, Tom A.

PY - 1992/12/1

Y1 - 1992/12/1

N2 - To identify components of the mammalian endoplasmic reticulum involved in the translocation of secretory proteins, crosslinking and reconstitution methods were combined. A multispanning abundant membrane glycoprotein was found which is in proximity to nascent chains early in translocation. In reconstituted proteoliposomes, this protein is stimulatory or required for the translocation of secretory proteins.

AB - To identify components of the mammalian endoplasmic reticulum involved in the translocation of secretory proteins, crosslinking and reconstitution methods were combined. A multispanning abundant membrane glycoprotein was found which is in proximity to nascent chains early in translocation. In reconstituted proteoliposomes, this protein is stimulatory or required for the translocation of secretory proteins.

UR - http://www.scopus.com/inward/record.url?scp=0026504192&partnerID=8YFLogxK

M3 - Journal articles

C2 - 1315422

AN - SCOPUS:0026504192

SN - 0028-0836

VL - 357

SP - 47

EP - 52

JO - Nature

JF - Nature

IS - 6373

ER -

A protein of the endoplasmic reticulum involved early in polypeptide translocation

Abstract

UN SDGs

Other files and links

Fingerprint

Cite this