A prepro-orexin gene polymorphism is associated with narcolepsy

M. Gencik; N. Dahmen; S. Wieczorek; M. Kasten; J. Bierbrauer; I. Anghelescu; A. Szegedi; A. M. Menezes Saecker; J. T. Epplen

doi:10.1212/WNL.56.1.115

A prepro-orexin gene polymorphism is associated with narcolepsy

M. Gencik^*, N. Dahmen, S. Wieczorek, M. Kasten, J. Bierbrauer, I. Anghelescu, A. Szegedi, A. M. Menezes Saecker, J. T. Epplen

^*Corresponding author for this work

Clinic of Psychiatry and Psychotherapy

54 Citations (Scopus)

Abstract

The orexin (hypocretin) neurotransmitter system was recently shown to be directly involved in the pathogenesis of narcolepsy in two animal models. Furthermore, decreased levels of orexin A in the CSF were shown in narcoleptic patients. To define any genetic contribution of orexin to the etiology of narcolepsy, the authors screened the entire prepro-orexin gene for mutations or polymorphisms in 133 patients suffering from narcolepsy. They report an association of a rare polymorphism in the prepro-orexin gene with narcolepsy in a cohort of 178 patients.

Original language	English
Journal	Neurology
Volume	56
Issue number	1
Pages (from-to)	115-117
Number of pages	3
ISSN	0028-3878
DOIs	https://doi.org/10.1212/WNL.56.1.115
Publication status	Published - 09.01.2001

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title = "A prepro-orexin gene polymorphism is associated with narcolepsy",

abstract = "The orexin (hypocretin) neurotransmitter system was recently shown to be directly involved in the pathogenesis of narcolepsy in two animal models. Furthermore, decreased levels of orexin A in the CSF were shown in narcoleptic patients. To define any genetic contribution of orexin to the etiology of narcolepsy, the authors screened the entire prepro-orexin gene for mutations or polymorphisms in 133 patients suffering from narcolepsy. They report an association of a rare polymorphism in the prepro-orexin gene with narcolepsy in a cohort of 178 patients.",

author = "M. Gencik and N. Dahmen and S. Wieczorek and M. Kasten and J. Bierbrauer and I. Anghelescu and A. Szegedi and {Menezes Saecker}, {A. M.} and Epplen, {J. T.}",

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doi = "10.1212/WNL.56.1.115",

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T1 - A prepro-orexin gene polymorphism is associated with narcolepsy

AU - Gencik, M.

AU - Dahmen, N.

AU - Wieczorek, S.

AU - Kasten, M.

AU - Bierbrauer, J.

AU - Anghelescu, I.

AU - Szegedi, A.

AU - Menezes Saecker, A. M.

AU - Epplen, J. T.

PY - 2001/1/9

Y1 - 2001/1/9

N2 - The orexin (hypocretin) neurotransmitter system was recently shown to be directly involved in the pathogenesis of narcolepsy in two animal models. Furthermore, decreased levels of orexin A in the CSF were shown in narcoleptic patients. To define any genetic contribution of orexin to the etiology of narcolepsy, the authors screened the entire prepro-orexin gene for mutations or polymorphisms in 133 patients suffering from narcolepsy. They report an association of a rare polymorphism in the prepro-orexin gene with narcolepsy in a cohort of 178 patients.

AB - The orexin (hypocretin) neurotransmitter system was recently shown to be directly involved in the pathogenesis of narcolepsy in two animal models. Furthermore, decreased levels of orexin A in the CSF were shown in narcoleptic patients. To define any genetic contribution of orexin to the etiology of narcolepsy, the authors screened the entire prepro-orexin gene for mutations or polymorphisms in 133 patients suffering from narcolepsy. They report an association of a rare polymorphism in the prepro-orexin gene with narcolepsy in a cohort of 178 patients.

UR - http://www.scopus.com/inward/record.url?scp=0035830409&partnerID=8YFLogxK

U2 - 10.1212/WNL.56.1.115

DO - 10.1212/WNL.56.1.115

M3 - Journal articles

AN - SCOPUS:0035830409

SN - 0028-3878

VL - 56

SP - 115

EP - 117

JO - Neurology

JF - Neurology

IS - 1

ER -

A prepro-orexin gene polymorphism is associated with narcolepsy

Abstract

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