TY - JOUR
T1 - A pooled analysis of Melanocytic nevus phenotype and the risk of cutaneous melanoma at different latitudes
AU - Chang, Yu Mei
AU - Newton-Bishop, Julia A.
AU - Bishop, D. Timothy
AU - Armstrong, Bruce K.
AU - Bataille, Veronique
AU - Bergman, Wilma
AU - Berwick, Marianne
AU - Bracci, Paige M.
AU - Elwood, J. Mark
AU - Ernstoff, Marc S.
AU - Green, Adèle C.
AU - Gruis, Nelleke A.
AU - Holly, Elizabeth A.
AU - Ingvar, Christian
AU - Kanetsky, Peter A.
AU - Karagas, Margaret R.
AU - Marchand, Loïc Le
AU - Mackie, Rona M.
AU - Olsson, Håkan
AU - Østerlind, Anne
AU - Rebbeck, Timothy R.
AU - Reich, Kristian
AU - Sasieni, Peter
AU - Siskind, Victor
AU - Swerdlow, Anthony J.
AU - Titus-Ernstoff, Linda
AU - Zens, Michael S.
AU - Ziegler, Andreas
AU - Barrett, Jennifer H.
PY - 2009/1/15
Y1 - 2009/1/15
N2 - An abnormal nevus phenotype is associated with an increased risk of melanoma. We report a pooled analysis conducted using individual nevus data from 15 case-control studies (5,421 melanoma cases and 6,966 controls). The aims were to quantify the risk better and to determine whether relative risk is varied by latitude. Bayesian unconditional logistic random coefficients models were employed to study the risk associated with nevus characteristics. Participants with whole body nevus counts in the highest of 4 population-based categories had a greatly increased risk of melanoma compared with those in the lowest category (pooled odds ratio (pOR) 6.9 (95% confidence interval (CI): 4.4,11.2) for those aged <50 years and pOR 5.1 (95% CI: 3.6, 7.5) for those aged ≥50). The pOR for presence compared with absence of any clinically atypical nevi was 4.0 (95% CI: 2.8, 5.8). The pORs for 1-2 and ≥3 large nevi on the body compared with none were 2.9 (95% CI: 1.9, 4.3) and 7.1 (95% CI: 4.7, 11.6), respectively. The relative heterogeneities among studies were small for most measures of nevus phenotype, except for the analysis of nevus counts on the arms, which may have been due to methodological differences among studies. The pooled analysis also suggested that an abnormal nevus phenotype is associated most with melanomas on intermittently sun-exposed sites. The presence of increased numbers of nevi, large nevi and clinically atypical nevi on the body are robust risk factors for melanoma showing little variation in relative risk among studies performed at different latitudes.
AB - An abnormal nevus phenotype is associated with an increased risk of melanoma. We report a pooled analysis conducted using individual nevus data from 15 case-control studies (5,421 melanoma cases and 6,966 controls). The aims were to quantify the risk better and to determine whether relative risk is varied by latitude. Bayesian unconditional logistic random coefficients models were employed to study the risk associated with nevus characteristics. Participants with whole body nevus counts in the highest of 4 population-based categories had a greatly increased risk of melanoma compared with those in the lowest category (pooled odds ratio (pOR) 6.9 (95% confidence interval (CI): 4.4,11.2) for those aged <50 years and pOR 5.1 (95% CI: 3.6, 7.5) for those aged ≥50). The pOR for presence compared with absence of any clinically atypical nevi was 4.0 (95% CI: 2.8, 5.8). The pORs for 1-2 and ≥3 large nevi on the body compared with none were 2.9 (95% CI: 1.9, 4.3) and 7.1 (95% CI: 4.7, 11.6), respectively. The relative heterogeneities among studies were small for most measures of nevus phenotype, except for the analysis of nevus counts on the arms, which may have been due to methodological differences among studies. The pooled analysis also suggested that an abnormal nevus phenotype is associated most with melanomas on intermittently sun-exposed sites. The presence of increased numbers of nevi, large nevi and clinically atypical nevi on the body are robust risk factors for melanoma showing little variation in relative risk among studies performed at different latitudes.
UR - http://www.scopus.com/inward/record.url?scp=58249084342&partnerID=8YFLogxK
U2 - 10.1002/ijc.23869
DO - 10.1002/ijc.23869
M3 - Journal articles
C2 - 18792098
AN - SCOPUS:58249084342
VL - 124
SP - 420
EP - 428
JO - International Journal of Cancer
JF - International Journal of Cancer
SN - 0020-7136
IS - 2
ER -