A novel “complement–metabolism–inflammasome axis” as a key regulator of immune cell effector function

Giuseppina Arbore, Claudia Kemper*

*Corresponding author for this work
56 Citations (Scopus)


The inflammasomes are intracellular multiprotein complexes that induce and regulate the generation of the key pro-inflammatory cytokines IL-1β and IL-18 in response to infectious microbes and cellular stress. The activation of inflammasomes involves several upstream signals including classic pattern or danger recognition systems such as the TLRs. Recently, however, the activation of complement receptors, such as the anaphylatoxin C3a and C5a receptors and the complement regulator CD46, in conjunction with the sensing of cell metabolic changes, for instance increased amino acid influx and glycolysis (via mTORC1), have emerged as additional critical activators of the inflammasome. This review summarizes recent advances in our knowledge about complement-mediated inflammasome activation, with a specific focus on a novel “complement – metabolism – NLRP3 inflammasome axis.”.

Original languageEnglish
JournalEuropean Journal of Immunology
Issue number7
Pages (from-to)1563-1573
Number of pages11
Publication statusPublished - 01.07.2016

Research Areas and Centers

  • Academic Focus: Center for Infection and Inflammation Research (ZIEL)


Dive into the research topics of 'A novel “complement–metabolism–inflammasome axis” as a key regulator of immune cell effector function'. Together they form a unique fingerprint.

Cite this