TY - JOUR
T1 - A novel “complement–metabolism–inflammasome axis” as a key regulator of immune cell effector function
AU - Arbore, Giuseppina
AU - Kemper, Claudia
N1 - Publisher Copyright:
© 2016 The Authors. European Journal of Immunology published by WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
PY - 2016/7/1
Y1 - 2016/7/1
N2 - The inflammasomes are intracellular multiprotein complexes that induce and regulate the generation of the key pro-inflammatory cytokines IL-1β and IL-18 in response to infectious microbes and cellular stress. The activation of inflammasomes involves several upstream signals including classic pattern or danger recognition systems such as the TLRs. Recently, however, the activation of complement receptors, such as the anaphylatoxin C3a and C5a receptors and the complement regulator CD46, in conjunction with the sensing of cell metabolic changes, for instance increased amino acid influx and glycolysis (via mTORC1), have emerged as additional critical activators of the inflammasome. This review summarizes recent advances in our knowledge about complement-mediated inflammasome activation, with a specific focus on a novel “complement – metabolism – NLRP3 inflammasome axis.”.
AB - The inflammasomes are intracellular multiprotein complexes that induce and regulate the generation of the key pro-inflammatory cytokines IL-1β and IL-18 in response to infectious microbes and cellular stress. The activation of inflammasomes involves several upstream signals including classic pattern or danger recognition systems such as the TLRs. Recently, however, the activation of complement receptors, such as the anaphylatoxin C3a and C5a receptors and the complement regulator CD46, in conjunction with the sensing of cell metabolic changes, for instance increased amino acid influx and glycolysis (via mTORC1), have emerged as additional critical activators of the inflammasome. This review summarizes recent advances in our knowledge about complement-mediated inflammasome activation, with a specific focus on a novel “complement – metabolism – NLRP3 inflammasome axis.”.
UR - http://www.scopus.com/inward/record.url?scp=84978288635&partnerID=8YFLogxK
U2 - 10.1002/eji.201546131
DO - 10.1002/eji.201546131
M3 - Journal articles
C2 - 27184294
AN - SCOPUS:84978288635
SN - 0014-2980
VL - 46
SP - 1563
EP - 1573
JO - European Journal of Immunology
JF - European Journal of Immunology
IS - 7
ER -