TY - JOUR
T1 - A New Tool Predicting Survival After Radiosurgery Alone for One or Two Cerebral Metastases from Lung Cancer
AU - Rades, Dirk
AU - Huttenlocher, Stefan
AU - Dziggel, Liesa
AU - Khoa, Mai Trong
AU - Van Thai, Pham
AU - Hornung, Dagmar
AU - Schild, Steven E.
N1 - Publisher Copyright:
© 2014, Springer Science+Business Media New York.
Copyright:
Copyright 2017 Elsevier B.V., All rights reserved.
PY - 2015/3/19
Y1 - 2015/3/19
N2 - Radiosurgery is frequently used for patients with few cerebral metastases. Decisions regarding personalized treatment should include the patient’s survival prognosis. Prognostic tools should be available for estimating the remaining lifetime for each primary tumor and treatment. We designed such a tool for patients receiving radiosurgery alone for cerebral metastases from lung cancer. Ten variables were analyzed in 98 patients. On multivariate analysis, extra-cranial spread was significantly associated with worse survival (p < 0.001). A trend was observed for poorer performance status (p = 0.08) and greater diameter of cerebral lesions (p = 0.07). Points for the tool were derived from 12-month survival rates of these variables and added, resulting in sum scores of 10–16 points. Three groups were built, 10–12, 14–15, and 16 points with 12-month survival rates of 22, 52, and 79 % (p < 0.001). This new tool enables physicians to estimate the survival of lung cancer patients with few cerebral metastases which should impact individualized treatment choices.
AB - Radiosurgery is frequently used for patients with few cerebral metastases. Decisions regarding personalized treatment should include the patient’s survival prognosis. Prognostic tools should be available for estimating the remaining lifetime for each primary tumor and treatment. We designed such a tool for patients receiving radiosurgery alone for cerebral metastases from lung cancer. Ten variables were analyzed in 98 patients. On multivariate analysis, extra-cranial spread was significantly associated with worse survival (p < 0.001). A trend was observed for poorer performance status (p = 0.08) and greater diameter of cerebral lesions (p = 0.07). Points for the tool were derived from 12-month survival rates of these variables and added, resulting in sum scores of 10–16 points. Three groups were built, 10–12, 14–15, and 16 points with 12-month survival rates of 22, 52, and 79 % (p < 0.001). This new tool enables physicians to estimate the survival of lung cancer patients with few cerebral metastases which should impact individualized treatment choices.
UR - http://www.scopus.com/inward/record.url?scp=84925507957&partnerID=8YFLogxK
U2 - 10.1007/s00408-014-9676-4
DO - 10.1007/s00408-014-9676-4
M3 - Journal articles
C2 - 25528743
AN - SCOPUS:84925507957
SN - 0341-2040
VL - 193
SP - 299
EP - 302
JO - Lung
JF - Lung
IS - 2
ER -
