TY - JOUR
T1 - A new scoring-system for estimating overall survival after radiotherapy of recurrent head and neck cancers
AU - Rades, Dirk
AU - Seidl, Daniel
AU - Janssen, Stefan
AU - Hakim, Samer G.
AU - Wollenberg, Barbara
AU - Bartscht, Tobias
AU - Schild, Steven E.
N1 - Publisher Copyright:
© 2018 International Institute of Anticancer Research. All rights reserved.
Copyright:
Copyright 2018 Elsevier B.V., All rights reserved.
PY - 2018/3
Y1 - 2018/3
N2 - Background/Aim: Locoregional recurrences of head and neck cancers are often associated with a poor overall survival (OS). Outcomes may be improved with individualized treatments considering a patient’s lifespan. A specific scoring system for estimating OS prognoses is presented. Patients and Methods: In a preceding study of these 60 patients, Eastern Cooperative Oncology Group performance score (ECOG 0-1 versus 2, p=0.002) and N-stage (N0-1 versus N2, p=0.004) were identified as independent predictors of OS. Results: In the current study, the following scoring points were assigned: ECOG performance score 2=0 points, ECOG performance score 0-1=1 point, N2=0 points, N0-1=1 point. Patient scores were 0, 1 or 2 points with 3-year OS rates of 0%, 46% and 83%, respectively (p<0.0001). On multivariable analysis, differences remained significant (p<0.0001). Conclusion: This new scoring system includes three groups of patients with significantly different OS prognoses and can assist physicians when designing individualized therapy for locoregional recurrences of head and neck cancer.
AB - Background/Aim: Locoregional recurrences of head and neck cancers are often associated with a poor overall survival (OS). Outcomes may be improved with individualized treatments considering a patient’s lifespan. A specific scoring system for estimating OS prognoses is presented. Patients and Methods: In a preceding study of these 60 patients, Eastern Cooperative Oncology Group performance score (ECOG 0-1 versus 2, p=0.002) and N-stage (N0-1 versus N2, p=0.004) were identified as independent predictors of OS. Results: In the current study, the following scoring points were assigned: ECOG performance score 2=0 points, ECOG performance score 0-1=1 point, N2=0 points, N0-1=1 point. Patient scores were 0, 1 or 2 points with 3-year OS rates of 0%, 46% and 83%, respectively (p<0.0001). On multivariable analysis, differences remained significant (p<0.0001). Conclusion: This new scoring system includes three groups of patients with significantly different OS prognoses and can assist physicians when designing individualized therapy for locoregional recurrences of head and neck cancer.
UR - http://www.scopus.com/inward/record.url?scp=85043446033&partnerID=8YFLogxK
U2 - 10.21873/anticanres.12391
DO - 10.21873/anticanres.12391
M3 - Journal articles
C2 - 29491092
AN - SCOPUS:85043446033
SN - 0250-7005
VL - 38
SP - 1611
EP - 1613
JO - Anticancer Research
JF - Anticancer Research
IS - 3
ER -