A new candidate for the regulation of erythropoiesis. Insulin-like growth factor I

Armin Kurtz; Wolfgang Jelkmann; Christian Bauer

doi:10.1016/0014-5793(82)81081-8

A new candidate for the regulation of erythropoiesis. Insulin-like growth factor I

Armin Kurtz^*, Wolfgang Jelkmann, Christian Bauer

^*Corresponding author for this work

Institute of Physiology

University of Regensburg

66 Citations (Scopus)

Abstract

The effect of pure human insulin-like growth factor I (IGF I) on the colony formation of late stage erythroid precursor cells (CFU-e) from fetal mouse liver and adult bone marrow was studied in a serum-free culture system. We found that IGF I in physiological concentrations stimulated erythroid colony formation. The combined effect of IGF I and erythropoietin was smaller than the sum of their single effects. The number of colonies induced by IGF I was linearly dependent on the number of plated cells. Our results indicate that IGF I is the first early defined mitogen that stimulates the late stages of erythroid differentiation independently of erythropoietin.

Original language	English
Journal	FEBS Letters
Volume	149
Issue number	1
Pages (from-to)	105-108
Number of pages	4
ISSN	0014-5793
DOIs	https://doi.org/10.1016/0014-5793(82)81081-8
Publication status	Published - 22.11.1982

Funding

Our sincere thanks are to Professor E.R. Froesch for supplyingu s with IGF I. This work was financially supported by the Sonderfor-schungsbereich4 3 of the DeutscheF orschungs-gemeinscha.f t

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Research Areas and Centers

Academic Focus: Center for Brain, Behavior and Metabolism (CBBM)

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Cite this

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title = "A new candidate for the regulation of erythropoiesis. Insulin-like growth factor I",

abstract = "The effect of pure human insulin-like growth factor I (IGF I) on the colony formation of late stage erythroid precursor cells (CFU-e) from fetal mouse liver and adult bone marrow was studied in a serum-free culture system. We found that IGF I in physiological concentrations stimulated erythroid colony formation. The combined effect of IGF I and erythropoietin was smaller than the sum of their single effects. The number of colonies induced by IGF I was linearly dependent on the number of plated cells. Our results indicate that IGF I is the first early defined mitogen that stimulates the late stages of erythroid differentiation independently of erythropoietin.",

author = "Armin Kurtz and Wolfgang Jelkmann and Christian Bauer",

note = "Funding Information: Our sincere thanks are to Professor E.R. Froesch for supplyingu s with IGF I. This work was financially supported by the Sonderfor-schungsbereich4 3 of the DeutscheF orschungs-gemeinscha.f t Copyright: Copyright 2014 Elsevier B.V., All rights reserved.",

year = "1982",

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doi = "10.1016/0014-5793(82)81081-8",

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T1 - A new candidate for the regulation of erythropoiesis. Insulin-like growth factor I

AU - Kurtz, Armin

AU - Jelkmann, Wolfgang

AU - Bauer, Christian

N1 - Funding Information: Our sincere thanks are to Professor E.R. Froesch for supplyingu s with IGF I. This work was financially supported by the Sonderfor-schungsbereich4 3 of the DeutscheF orschungs-gemeinscha.f t Copyright: Copyright 2014 Elsevier B.V., All rights reserved.

PY - 1982/11/22

Y1 - 1982/11/22

N2 - The effect of pure human insulin-like growth factor I (IGF I) on the colony formation of late stage erythroid precursor cells (CFU-e) from fetal mouse liver and adult bone marrow was studied in a serum-free culture system. We found that IGF I in physiological concentrations stimulated erythroid colony formation. The combined effect of IGF I and erythropoietin was smaller than the sum of their single effects. The number of colonies induced by IGF I was linearly dependent on the number of plated cells. Our results indicate that IGF I is the first early defined mitogen that stimulates the late stages of erythroid differentiation independently of erythropoietin.

AB - The effect of pure human insulin-like growth factor I (IGF I) on the colony formation of late stage erythroid precursor cells (CFU-e) from fetal mouse liver and adult bone marrow was studied in a serum-free culture system. We found that IGF I in physiological concentrations stimulated erythroid colony formation. The combined effect of IGF I and erythropoietin was smaller than the sum of their single effects. The number of colonies induced by IGF I was linearly dependent on the number of plated cells. Our results indicate that IGF I is the first early defined mitogen that stimulates the late stages of erythroid differentiation independently of erythropoietin.

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U2 - 10.1016/0014-5793(82)81081-8

DO - 10.1016/0014-5793(82)81081-8

M3 - Journal articles

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AN - SCOPUS:0020393390

SN - 0014-5793

VL - 149

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JO - FEBS Letters

JF - FEBS Letters

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ER -

A new candidate for the regulation of erythropoiesis. Insulin-like growth factor I

Abstract

Funding

UN SDGs

Research Areas and Centers

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