Abstract
The effect of pure human insulin-like growth factor I (IGF I) on the colony formation of late stage erythroid precursor cells (CFU-e) from fetal mouse liver and adult bone marrow was studied in a serum-free culture system. We found that IGF I in physiological concentrations stimulated erythroid colony formation. The combined effect of IGF I and erythropoietin was smaller than the sum of their single effects. The number of colonies induced by IGF I was linearly dependent on the number of plated cells. Our results indicate that IGF I is the first early defined mitogen that stimulates the late stages of erythroid differentiation independently of erythropoietin.
Original language | English |
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Journal | FEBS Letters |
Volume | 149 |
Issue number | 1 |
Pages (from-to) | 105-108 |
Number of pages | 4 |
ISSN | 0014-5793 |
DOIs | |
Publication status | Published - 22.11.1982 |
Research Areas and Centers
- Academic Focus: Center for Brain, Behavior and Metabolism (CBBM)