A new candidate for the regulation of erythropoiesis. Insulin-like growth factor I

Armin Kurtz*, Wolfgang Jelkmann, Christian Bauer

*Corresponding author for this work
58 Citations (Scopus)

Abstract

The effect of pure human insulin-like growth factor I (IGF I) on the colony formation of late stage erythroid precursor cells (CFU-e) from fetal mouse liver and adult bone marrow was studied in a serum-free culture system. We found that IGF I in physiological concentrations stimulated erythroid colony formation. The combined effect of IGF I and erythropoietin was smaller than the sum of their single effects. The number of colonies induced by IGF I was linearly dependent on the number of plated cells. Our results indicate that IGF I is the first early defined mitogen that stimulates the late stages of erythroid differentiation independently of erythropoietin.

Original languageEnglish
JournalFEBS Letters
Volume149
Issue number1
Pages (from-to)105-108
Number of pages4
ISSN0014-5793
DOIs
Publication statusPublished - 22.11.1982

Research Areas and Centers

  • Academic Focus: Center for Brain, Behavior and Metabolism (CBBM)

Fingerprint

Dive into the research topics of 'A new candidate for the regulation of erythropoiesis. Insulin-like growth factor I'. Together they form a unique fingerprint.

Cite this