A new balloon catheter system used for PDT in the human urinary bladder, accuracy of light distribution

Rolf H. Eichenauer*, Gereon Hüttmann, Stephan Wörmer, Norbert Koop, Wolfgang Beyer, Dieter Jocham

*Corresponding author for this work

Abstract

Photodynamic therapy (PDT) may provide a new approach for treatment of patients with superficial transitional carcinoma and carcinoma in situ of the bladder. The light applicator for the bladder wall (Rüsch) is constructed as a balloon catheter with two concentric balloons. A new PDT applicator (Rüsch) was assessed for the homogenity and accuracy of irradiation during PDT. In an in-vitro experiment with 17 freshly harvested porcine bladders the fluence rate was measured locally with-isotropic detectors. The results were compared to the light fluence detected by the PDT applicator. The increase of the fluence rate β inside the bladders due to back scattering ranged between 5.3 and 7.0 with an average of 6.2. Local variations of the fluence rate in the sperical bladders were also smaller than 15%. Therefore it is concluded, that a homogeneous and accurate irradiation during PDT is possible. Blood between the outer balloon and the bladder wall reduces the local fluence rate strongly and should to be avoided. Also larger air bubbles in the applicator can lead to an inhomogeneous light distribution. In regular application the presented new catheter system provides accurate and easy light dosimetry during PDT of the bladder. Attention had to be paid to a continuous flushing of the space between balloon and bladder wall in order to prevent the accumulation of urine and blood. To avoid a malfunction of the system and large errors in light dosimetry and application, it is advisable to monitor the measured light dosage and the shape of the balloon using ultrasonography during PDT.

Original languageEnglish
Title of host publicationOptical Methods for Tumor Treatment and Detections: Mechanisms and Techniques in Photodynamic Therapy VII
EditorsThomas J. Dougherty
Number of pages7
Volume3247
PublisherSPIE
Publication date19.05.1998
Pages138-144
DOIs
Publication statusPublished - 19.05.1998
EventOptical methods for Tumor Treatment and Detections: Mechanisms and Techniques in Photodynamic Therapy VII - San Jose, United States
Duration: 24.01.199825.01.1998
Conference number: 59609

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