TY - JOUR
T1 - A negative breakdown test in a fragrance mix I-positive patient does not rule out contact allergy to its fragrance constituents
AU - for the Information Network of Departments of Dermatology
AU - Geier, Johannes
AU - Schubert, Steffen
AU - Schnuch, Axel
AU - Szliska, Christiane
AU - Weisshaar, Elke
AU - Kränke, Birger
AU - Werfel, Thomas
AU - Ruëff, Franziska
AU - Schröder-Kraft, Claudia
AU - Buhl, Timo
AU - Baron, Jens Malte
AU - Grabbe, Jürgen
AU - Siedlecki, Katharina
AU - Strom, Kerstin
AU - Hofmeier, Kathrin Scherer
AU - Worm, Margitta
AU - Simon, Dagmar
AU - Effendy, Isaak
AU - Dickel, Heinrich
AU - Fartasch, Manigé
AU - Vieluf, Dieter
AU - Beiteke, Ulrike
AU - Bauer, Andrea
AU - Koch, André
AU - Wagner, Nicola
AU - Dissemond, Joachim
AU - Gina, Michal
AU - Grunwald-Delitz, Heidrun
AU - Jünger, Michael
AU - Kreft, Burkhard
AU - Witte, Jana
AU - Schäkel, Knut
AU - Löffler, Harald
AU - Pföhler, Claudia
AU - Schliemann, Sibylle
AU - Heine, Guido
AU - Spring, Philipp
AU - Treudler, Regina
AU - Nestoris, Stefan
AU - Recke, Andreas
AU - Becker, Detlef
AU - Schmieder, Astrid
AU - Pfützner, Wolfgang
AU - Stadler, Rudolf
AU - Coras-Stepanek, Brigitte
AU - Brockow, Knut
AU - Brehler, Randolf
AU - Baur, Vera
AU - Raap, Ulrike
AU - Skudlik, Christoph
N1 - Publisher Copyright:
© 2021 The Authors. Contact Dermatitis published by John Wiley & Sons Ltd.
PY - 2021/6
Y1 - 2021/6
N2 - Background: In about half of the patients reacting positive to fragrance mix I (FM I), breakdown testing remains negative. This raises the question of whether the reaction to FM I is false-positive, or the breakdown test is false-negative. Objectives: To identify characteristics and sensitization patterns of patients positive to FM I, but not to its fragrance constituents. Patients and Methods: Retrospective analysis of data from the Information Network of Departments of Dermatology (IVDK) between 2005 and 2019. Three patient groups were defined according to their reaction pattern: Group I, FM I positive and ≥1 single fragrance positive in the breakdown test (n = 1912); Group II, FM I positive and breakdown test negative (n = 1318); Group III, FM I negative (n = 19 790). Results: Regarding the pattern of concomitant reactions to other fragrances, Group II had an intermediate position between Group I and Group III. In other respects (age and sex distribution, frequency of sensitization to non-fragrance baseline series allergens), Group II rather resembled Group I. Conclusions: Not every positive reaction to FM I in patients with negative breakdown tests is false-positive. There may be false-negative reactions to the single fragrance components when patch tested at 1% pet. Raising patch concentrations of some single fragrances is recommended.
AB - Background: In about half of the patients reacting positive to fragrance mix I (FM I), breakdown testing remains negative. This raises the question of whether the reaction to FM I is false-positive, or the breakdown test is false-negative. Objectives: To identify characteristics and sensitization patterns of patients positive to FM I, but not to its fragrance constituents. Patients and Methods: Retrospective analysis of data from the Information Network of Departments of Dermatology (IVDK) between 2005 and 2019. Three patient groups were defined according to their reaction pattern: Group I, FM I positive and ≥1 single fragrance positive in the breakdown test (n = 1912); Group II, FM I positive and breakdown test negative (n = 1318); Group III, FM I negative (n = 19 790). Results: Regarding the pattern of concomitant reactions to other fragrances, Group II had an intermediate position between Group I and Group III. In other respects (age and sex distribution, frequency of sensitization to non-fragrance baseline series allergens), Group II rather resembled Group I. Conclusions: Not every positive reaction to FM I in patients with negative breakdown tests is false-positive. There may be false-negative reactions to the single fragrance components when patch tested at 1% pet. Raising patch concentrations of some single fragrances is recommended.
UR - http://www.scopus.com/inward/record.url?scp=85101901677&partnerID=8YFLogxK
UR - https://www.mendeley.com/catalogue/db02143b-5511-3240-b5db-a378fa7264ae/
U2 - 10.1111/cod.13803
DO - 10.1111/cod.13803
M3 - Journal articles
C2 - 33533485
AN - SCOPUS:85101901677
SN - 0105-1873
VL - 84
SP - 407
EP - 418
JO - Contact Dermatitis
JF - Contact Dermatitis
IS - 6
ER -