A Narrative Review - Therapy Options and Therapy Failure in Retinoblastoma

Argyrios Chronopoulos; Neele Babst; Christian Schiemenz; James S. Schutz; Ludwig M. Heindl; Mahdy Ranjbar; Vinodh Kakkassery

doi:10.33594/000000585

A Narrative Review - Therapy Options and Therapy Failure in Retinoblastoma

Argyrios Chronopoulos, Neele Babst, Christian Schiemenz, James S. Schutz, Ludwig M. Heindl, Mahdy Ranjbar, Vinodh Kakkassery

Clinic of Ophtalmology

3 Citations (Scopus)

Abstract

Retinoblastoma (RB) management has evolved over the last three decades. Goals of modern RB treatment are first to protect life and prevent metastatic disease, then preservation of the globe and useful vision. With modern treatment protocols and early disease detection success rates can reach up to 100% of disease-free-globe and eye preservation. Treatment of advanced cases remains complex, requiring aggressive chemotherapy or/and external beam radiation. Treatment protocols are extremely diverse and dependent on local resources thus success rates are variable. Here we review narratively current treatment protocols and failure rates based on a PubMed search using keywords of retinoblastoma, retinoblastoma seed, retinoblastoma treatment, enucleation.

Original language	English
Journal	NeuroSignals
Volume	30
Pages (from-to)	39-58
Number of pages	20
ISSN	1424-862X
DOIs	https://doi.org/10.33594/000000585
Publication status	Published - 2022

Research Areas and Centers

Research Area: Luebeck Integrated Oncology Network (LION)
Centers: University Cancer Center Schleswig-Holstein (UCCSH)

DFG Research Classification Scheme

205-14 Haematology, Oncology
206-11 Ophthalmology

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.33594/000000585

Cite this

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title = "A Narrative Review - Therapy Options and Therapy Failure in Retinoblastoma",

abstract = "Retinoblastoma (RB) management has evolved over the last three decades. Goals of modern RB treatment are first to protect life and prevent metastatic disease, then preservation of the globe and useful vision. With modern treatment protocols and early disease detection success rates can reach up to 100% of disease-free-globe and eye preservation. Treatment of advanced cases remains complex, requiring aggressive chemotherapy or/and external beam radiation. Treatment protocols are extremely diverse and dependent on local resources thus success rates are variable. Here we review narratively current treatment protocols and failure rates based on a PubMed search using keywords of retinoblastoma, retinoblastoma seed, retinoblastoma treatment, enucleation.",

author = "Argyrios Chronopoulos and Neele Babst and Christian Schiemenz and Schutz, {James S.} and Heindl, {Ludwig M.} and Mahdy Ranjbar and Vinodh Kakkassery",

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year = "2022",

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T1 - A Narrative Review - Therapy Options and Therapy Failure in Retinoblastoma

AU - Chronopoulos, Argyrios

AU - Babst, Neele

AU - Schiemenz, Christian

AU - Schutz, James S.

AU - Heindl, Ludwig M.

AU - Ranjbar, Mahdy

AU - Kakkassery, Vinodh

PY - 2022

Y1 - 2022

N2 - Retinoblastoma (RB) management has evolved over the last three decades. Goals of modern RB treatment are first to protect life and prevent metastatic disease, then preservation of the globe and useful vision. With modern treatment protocols and early disease detection success rates can reach up to 100% of disease-free-globe and eye preservation. Treatment of advanced cases remains complex, requiring aggressive chemotherapy or/and external beam radiation. Treatment protocols are extremely diverse and dependent on local resources thus success rates are variable. Here we review narratively current treatment protocols and failure rates based on a PubMed search using keywords of retinoblastoma, retinoblastoma seed, retinoblastoma treatment, enucleation.

AB - Retinoblastoma (RB) management has evolved over the last three decades. Goals of modern RB treatment are first to protect life and prevent metastatic disease, then preservation of the globe and useful vision. With modern treatment protocols and early disease detection success rates can reach up to 100% of disease-free-globe and eye preservation. Treatment of advanced cases remains complex, requiring aggressive chemotherapy or/and external beam radiation. Treatment protocols are extremely diverse and dependent on local resources thus success rates are variable. Here we review narratively current treatment protocols and failure rates based on a PubMed search using keywords of retinoblastoma, retinoblastoma seed, retinoblastoma treatment, enucleation.

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DO - 10.33594/000000585

M3 - Scientific review articles

C2 - 36354963

AN - SCOPUS:85141893258

SN - 1424-862X

VL - 30

SP - 39

EP - 58

JO - NeuroSignals

JF - NeuroSignals

ER -

A Narrative Review - Therapy Options and Therapy Failure in Retinoblastoma

Abstract

Research Areas and Centers

DFG Research Classification Scheme

UN SDGs

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