A Narrative Review - Therapy Options and Therapy Failure in Retinoblastoma

Argyrios Chronopoulos, Neele Babst, Christian Schiemenz, James S. Schutz, Ludwig M. Heindl, Mahdy Ranjbar, Vinodh Kakkassery

3 Citations (Scopus)


Retinoblastoma (RB) management has evolved over the last three decades. Goals of modern RB treatment are first to protect life and prevent metastatic disease, then preservation of the globe and useful vision. With modern treatment protocols and early disease detection success rates can reach up to 100% of disease-free-globe and eye preservation. Treatment of advanced cases remains complex, requiring aggressive chemotherapy or/and external beam radiation. Treatment protocols are extremely diverse and dependent on local resources thus success rates are variable. Here we review narratively current treatment protocols and failure rates based on a PubMed search using keywords of retinoblastoma, retinoblastoma seed, retinoblastoma treatment, enucleation.

Original languageEnglish
Pages (from-to)39-58
Number of pages20
Publication statusPublished - 2022

Research Areas and Centers

  • Research Area: Luebeck Integrated Oncology Network (LION)
  • Centers: University Cancer Center Schleswig-Holstein (UCCSH)

DFG Research Classification Scheme

  • 205-14 Haematology, Oncology
  • 206-11 Ophthalmology

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