Abstract
OLSON and WIJSMAN (1993) have proposed a robust linkage analysis between quantitative traits and a marker locus using all relative pairs. We extend their work to estimate the recombination fraction using a two-step procedure. In the first step Generalised Estimating Equations are solved. After robust linkage analysis minimum distance estimation is applied in the second step. Our approach requires a single codominant marker locus only. The relevant parameters of the genetic model can also be estimated by this method in the presence of linkage. We illustrate our approach by simulations.
| Original language | English |
|---|---|
| Journal | Biometrical Journal |
| Volume | 39 |
| Issue number | 7 |
| Pages (from-to) | 765-775 |
| Number of pages | 11 |
| ISSN | 0323-3847 |
| DOIs | |
| Publication status | Published - 1997 |
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SDG 3 Good Health and Well-being
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