A meta-analysis of the associations between insufficient sleep duration and antibody response to vaccination

Karine Spiegel*, Amandine E. Rey, Anne Cheylus, Kieran Ayling, Christian Benedict, Tanja Lange, Aric A. Prather, Daniel J. Taylor, Michael R. Irwin, Eve Van Cauter

*Corresponding author for this work
5 Citations (Scopus)

Abstract

Vaccination is a major strategy to control a viral pandemic. Simple behavioral interventions that might boost vaccine responses have yet to be identified. We conducted meta-analyses to summarize the evidence linking the amount of sleep obtained in the days surrounding vaccination to antibody response in healthy adults. Authors of the included studies provided the information needed to accurately estimate the pooled effect size (ES) and 95% confidence intervals (95% CI) and to examine sex differences.1,2,3,4,5,6,7 The association between self-reported short sleep (<6 h/night) and reduced vaccine response did not reach our pre-defined statistical significant criteria (total n = 504, ages 18–85; overall ES [95% CI] = 0.29 [−0.04, 0.63]). Objectively assessed short sleep was associated with a robust decrease in antibody response (total n = 304, ages 18–60; overall ES [95% CI] = 0.79 [0.40, 1.18]). In men, the pooled ES was large (overall ES [95% CI] = 0.93 [0.54, 1.33]), whereas it did not reach significance in women (overall ES [95% CI] = 0.42 [−0.49, 1.32]). These results provide evidence that insufficient sleep duration substantially decreases the response to anti-viral vaccination and suggests that achieving adequate amount of sleep during the days surrounding vaccination may enhance and prolong the humoral response. Large-scale well-controlled studies are urgently needed to define (1) the window of time around inoculation when optimizing sleep duration is most beneficial, (2) the causes of the sex disparity in the impact of sleep on the response, and (3) the amount of sleep needed to protect the response.

Original languageEnglish
JournalCurrent Biology
Volume33
Issue number5
Pages (from-to)998-1005.e2
ISSN0960-9822
DOIs
Publication statusPublished - 13.03.2023

Research Areas and Centers

  • Academic Focus: Center for Infection and Inflammation Research (ZIEL)

DFG Research Classification Scheme

  • 205-17 Endocrinology, Diabetology, Metabolism
  • 204-05 Immunology
  • 206-04 Cognitive, Systemic and Behavioural Neurobiology

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