TY - JOUR
T1 - A locus on chromosome 10 influences C-reactive protein levels in two independent populations
AU - Broeckel, Ulrich
AU - Hengstenberg, Christian
AU - Mayer, Bjoern
AU - Maresso, Karen
AU - Gaudet, Daniel
AU - Seda, Ondrej
AU - Tremblay, Johanne
AU - Holmer, Stephan
AU - Erdmann, Jeanette
AU - Glöckner, Christian
AU - Harrison, Michael
AU - Martin, Lisa J.
AU - Williams, Jeff T.
AU - Schmitz, Gerd
AU - Riegger, Guenter A.J.
AU - Jacob, Howard J.
AU - Hamet, Pavel
AU - Schunkert, Heribert
PY - 2007/8/1
Y1 - 2007/8/1
N2 - High sensitivity C-reactive protein (hsCRP) is an independent risk factor for cardiovascular disease, such as stroke or coronary artery disease. Genetic factors influence significantly the inter-individual variability of hsCRP. The aim of this study was to identify genomic regions influencing hsCRP levels. A genome scan was performed in two independent studies of Caucasian populations, namely 513 Western-European families ascertained for myocardial infarction (n = 1,406) and 120 French-Canadian families diagnosed with hypertension (n = 758). In the myocardial infarction families, 31% of the inter-individual variation of hsCRP levels was explained by genetic factors (P = 0.0000015) and loci influencing hsCRP were identified on chromosomes 10 (at 141 cM) and 5 (at 150 cM) with multipoint LOD scores of 3.15 and 2.23, respectively. An additional suggestive signal was detected on chromosome 2 in subset analyses. A similar degree of heritability has been observed in a second independent population of French-Canadian hypertensive families for hsCRP (30%) and linkage results for chromosome 10 were confirmed with maximum LOD score of 2.7. We identified a chromosomal region in two independent populations which influences hsCRP in addition to several unique regions. This provides targets for the identification of genes involved in the regulation of hsCRP and the development and progression of vascular disease, including stroke.
AB - High sensitivity C-reactive protein (hsCRP) is an independent risk factor for cardiovascular disease, such as stroke or coronary artery disease. Genetic factors influence significantly the inter-individual variability of hsCRP. The aim of this study was to identify genomic regions influencing hsCRP levels. A genome scan was performed in two independent studies of Caucasian populations, namely 513 Western-European families ascertained for myocardial infarction (n = 1,406) and 120 French-Canadian families diagnosed with hypertension (n = 758). In the myocardial infarction families, 31% of the inter-individual variation of hsCRP levels was explained by genetic factors (P = 0.0000015) and loci influencing hsCRP were identified on chromosomes 10 (at 141 cM) and 5 (at 150 cM) with multipoint LOD scores of 3.15 and 2.23, respectively. An additional suggestive signal was detected on chromosome 2 in subset analyses. A similar degree of heritability has been observed in a second independent population of French-Canadian hypertensive families for hsCRP (30%) and linkage results for chromosome 10 were confirmed with maximum LOD score of 2.7. We identified a chromosomal region in two independent populations which influences hsCRP in addition to several unique regions. This provides targets for the identification of genes involved in the regulation of hsCRP and the development and progression of vascular disease, including stroke.
UR - http://www.scopus.com/inward/record.url?scp=34447282010&partnerID=8YFLogxK
U2 - 10.1007/s00439-007-0380-9
DO - 10.1007/s00439-007-0380-9
M3 - Journal articles
C2 - 17530289
AN - SCOPUS:34447282010
SN - 0340-6717
VL - 122
SP - 95
EP - 102
JO - Human Genetics
JF - Human Genetics
IS - 1
ER -
