TY - JOUR
T1 - A fatal case of necrotizing sinusitis due to toxigenic Corynebacterium ulcerans
AU - Wellinghausen, Nele
AU - Sing, Andreas
AU - Kern, Winfried V.
AU - Perner, Sven
AU - Marre, Reinhard
AU - Rentschler, Jochen
N1 - Copyright:
Copyright 2017 Elsevier B.V., All rights reserved.
PY - 2002
Y1 - 2002
N2 - A 77-year-old farmer developed cough with sputum production, fever, bloody nasal discharge and a mass in his right maxillary sinus leading to necrotic ulceration of the sinus. Corynebacterium ulcerans, carrying the β-phage for the diphtheria toxin and secreting the toxin, was detected microscopically and by culture from the sinusoidal and ulcer discharge. Despite immediate antimicrobial chemotherapy the patient died of pulmonary failure associated with the production of large amounts of very viscous sputum. Identification of the causative agent, pathophysiological aspects and risk factors of this unusal infection are discussed.
AB - A 77-year-old farmer developed cough with sputum production, fever, bloody nasal discharge and a mass in his right maxillary sinus leading to necrotic ulceration of the sinus. Corynebacterium ulcerans, carrying the β-phage for the diphtheria toxin and secreting the toxin, was detected microscopically and by culture from the sinusoidal and ulcer discharge. Despite immediate antimicrobial chemotherapy the patient died of pulmonary failure associated with the production of large amounts of very viscous sputum. Identification of the causative agent, pathophysiological aspects and risk factors of this unusal infection are discussed.
UR - http://www.scopus.com/inward/record.url?scp=0035990511&partnerID=8YFLogxK
U2 - 10.1078/1438-4221-00186
DO - 10.1078/1438-4221-00186
M3 - Journal articles
C2 - 12139430
AN - SCOPUS:0035990511
SN - 1438-4221
VL - 292
SP - 59
EP - 63
JO - International Journal of Medical Microbiology
JF - International Journal of Medical Microbiology
IS - 1
ER -
