A dual role of linker histone H1.4 Lys 34 acetylation in transcriptional activation

Kinga Kamieniarz; Annalisa Izzo; Miroslav Dundr; Philipp Tropberger; Luka Ozretić; Jutta Kirfel; Elisabeth Scheer; Philippe Tropel; Jacek R. Wiśniewski; Laszlo Tora; Stephane Viville; Reinhard Buettner; Robert Schneider

doi:10.1101/gad.182014.111

A dual role of linker histone H1.4 Lys 34 acetylation in transcriptional activation

Kinga Kamieniarz, Annalisa Izzo, Miroslav Dundr, Philipp Tropberger, Luka Ozretić, Jutta Kirfel, Elisabeth Scheer, Philippe Tropel, Jacek R. Wiśniewski, Laszlo Tora, Stephane Viville, Reinhard Buettner, Robert Schneider^*

^*Corresponding author for this work

Institute of Pathology

84 Citations (Scopus)

Abstract

The linker histone H1 is a key player in chromatin organization, yet our understanding of the regulation of H1 functions by post-translational modifications is very limited. We provide here the first functional characterization of H1 acetylation. We show that H1.4K34 acetylation (H1.4K34ac) is mediated by GCN5 and is preferentially enriched at promoters of active genes, where it stimulates transcription by increasing H1 mobility and recruiting a general transcription factor. H1.4K34ac is dynamic during spermatogenesis and marks undifferentiated cells such as induced pluripotent stem (iPS) cells and testicular germ cell tumors. We propose a model for H1.4K34ac as a novel regulator of chromatin function with a dual role in transcriptional activation.

Original language	English
Journal	Genes and Development
Volume	26
Issue number	8
Pages (from-to)	797-802
Number of pages	6
ISSN	0890-9369
DOIs	https://doi.org/10.1101/gad.182014.111
Publication status	Published - 2012

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title = "A dual role of linker histone H1.4 Lys 34 acetylation in transcriptional activation",

abstract = "The linker histone H1 is a key player in chromatin organization, yet our understanding of the regulation of H1 functions by post-translational modifications is very limited. We provide here the first functional characterization of H1 acetylation. We show that H1.4K34 acetylation (H1.4K34ac) is mediated by GCN5 and is preferentially enriched at promoters of active genes, where it stimulates transcription by increasing H1 mobility and recruiting a general transcription factor. H1.4K34ac is dynamic during spermatogenesis and marks undifferentiated cells such as induced pluripotent stem (iPS) cells and testicular germ cell tumors. We propose a model for H1.4K34ac as a novel regulator of chromatin function with a dual role in transcriptional activation.",

author = "Kinga Kamieniarz and Annalisa Izzo and Miroslav Dundr and Philipp Tropberger and Luka Ozreti{\'c} and Jutta Kirfel and Elisabeth Scheer and Philippe Tropel and Wi{\'s}niewski, \{Jacek R.\} and Laszlo Tora and Stephane Viville and Reinhard Buettner and Robert Schneider",

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doi = "10.1101/gad.182014.111",

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T1 - A dual role of linker histone H1.4 Lys 34 acetylation in transcriptional activation

AU - Kamieniarz, Kinga

AU - Izzo, Annalisa

AU - Dundr, Miroslav

AU - Tropberger, Philipp

AU - Ozretić, Luka

AU - Kirfel, Jutta

AU - Scheer, Elisabeth

AU - Tropel, Philippe

AU - Wiśniewski, Jacek R.

AU - Tora, Laszlo

AU - Viville, Stephane

AU - Buettner, Reinhard

AU - Schneider, Robert

PY - 2012

Y1 - 2012

N2 - The linker histone H1 is a key player in chromatin organization, yet our understanding of the regulation of H1 functions by post-translational modifications is very limited. We provide here the first functional characterization of H1 acetylation. We show that H1.4K34 acetylation (H1.4K34ac) is mediated by GCN5 and is preferentially enriched at promoters of active genes, where it stimulates transcription by increasing H1 mobility and recruiting a general transcription factor. H1.4K34ac is dynamic during spermatogenesis and marks undifferentiated cells such as induced pluripotent stem (iPS) cells and testicular germ cell tumors. We propose a model for H1.4K34ac as a novel regulator of chromatin function with a dual role in transcriptional activation.

AB - The linker histone H1 is a key player in chromatin organization, yet our understanding of the regulation of H1 functions by post-translational modifications is very limited. We provide here the first functional characterization of H1 acetylation. We show that H1.4K34 acetylation (H1.4K34ac) is mediated by GCN5 and is preferentially enriched at promoters of active genes, where it stimulates transcription by increasing H1 mobility and recruiting a general transcription factor. H1.4K34ac is dynamic during spermatogenesis and marks undifferentiated cells such as induced pluripotent stem (iPS) cells and testicular germ cell tumors. We propose a model for H1.4K34ac as a novel regulator of chromatin function with a dual role in transcriptional activation.

UR - https://www.scopus.com/pages/publications/84859830821

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DO - 10.1101/gad.182014.111

M3 - Journal articles

C2 - 22465951

AN - SCOPUS:84859830821

SN - 0890-9369

VL - 26

SP - 797

EP - 802

JO - Genes and Development

JF - Genes and Development

IS - 8

ER -

A dual role of linker histone H1.4 Lys 34 acetylation in transcriptional activation

Abstract

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