A dual role for complement in allergic asthma

Jörg Köhl; Marsha Wills-Karp

doi:10.1016/j.coph.2007.01.005

A dual role for complement in allergic asthma

Jörg Köhl^*, Marsha Wills-Karp

^*Corresponding author for this work

Institute of Systemic Inflamation Research

University of Cincinnati

28 Citations (Scopus)

Abstract

Complement is an ancient danger-sensor system of innate immunity, providing first-line defence against pathogens. Concordant with its pro-inflammatory properties, complement contributes to airway inflammation, hyperresponsiveness and mucus production during the effector phase of allergic asthma. In contrast to these pro-allergic properties, complement can also protect from the development of the maladaptive Th2-biased immune response that drives airway inflammation and hyperreactivity in allergic asthma. As such, selective targeting of pro-allergic complement pathways appears an attractive therapeutic option in allergic asthma.

Original language	English
Journal	Current Opinion in Pharmacology
Volume	7
Issue number	3
Pages (from-to)	283-289
Number of pages	7
ISSN	1471-4892
DOIs	https://doi.org/10.1016/j.coph.2007.01.005
Publication status	Published - 01.06.2007

Funding

The authors acknowledge the support of NIH grants AI057839 to JK and HL58527, HL67736, HL66623 to MWK. We thank AG Lewis for critical reading of, and thoughtful comments on, the manuscript.

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.coph.2007.01.005

Cite this

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AB - Complement is an ancient danger-sensor system of innate immunity, providing first-line defence against pathogens. Concordant with its pro-inflammatory properties, complement contributes to airway inflammation, hyperresponsiveness and mucus production during the effector phase of allergic asthma. In contrast to these pro-allergic properties, complement can also protect from the development of the maladaptive Th2-biased immune response that drives airway inflammation and hyperreactivity in allergic asthma. As such, selective targeting of pro-allergic complement pathways appears an attractive therapeutic option in allergic asthma.

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A dual role for complement in allergic asthma

Abstract

Funding

UN SDGs

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