TY - JOUR
T1 - A dual role for complement in allergic asthma
AU - Köhl, Jörg
AU - Wills-Karp, Marsha
PY - 2007/6/1
Y1 - 2007/6/1
N2 - Complement is an ancient danger-sensor system of innate immunity, providing first-line defence against pathogens. Concordant with its pro-inflammatory properties, complement contributes to airway inflammation, hyperresponsiveness and mucus production during the effector phase of allergic asthma. In contrast to these pro-allergic properties, complement can also protect from the development of the maladaptive Th2-biased immune response that drives airway inflammation and hyperreactivity in allergic asthma. As such, selective targeting of pro-allergic complement pathways appears an attractive therapeutic option in allergic asthma.
AB - Complement is an ancient danger-sensor system of innate immunity, providing first-line defence against pathogens. Concordant with its pro-inflammatory properties, complement contributes to airway inflammation, hyperresponsiveness and mucus production during the effector phase of allergic asthma. In contrast to these pro-allergic properties, complement can also protect from the development of the maladaptive Th2-biased immune response that drives airway inflammation and hyperreactivity in allergic asthma. As such, selective targeting of pro-allergic complement pathways appears an attractive therapeutic option in allergic asthma.
UR - http://www.scopus.com/inward/record.url?scp=34248340981&partnerID=8YFLogxK
U2 - 10.1016/j.coph.2007.01.005
DO - 10.1016/j.coph.2007.01.005
M3 - Scientific review articles
C2 - 17475559
AN - SCOPUS:34248340981
SN - 1471-4892
VL - 7
SP - 283
EP - 289
JO - Current Opinion in Pharmacology
JF - Current Opinion in Pharmacology
IS - 3
ER -
