A dual role for complement in allergic asthma

Jörg Köhl*, Marsha Wills-Karp

*Corresponding author for this work
23 Citations (Scopus)


Complement is an ancient danger-sensor system of innate immunity, providing first-line defence against pathogens. Concordant with its pro-inflammatory properties, complement contributes to airway inflammation, hyperresponsiveness and mucus production during the effector phase of allergic asthma. In contrast to these pro-allergic properties, complement can also protect from the development of the maladaptive Th2-biased immune response that drives airway inflammation and hyperreactivity in allergic asthma. As such, selective targeting of pro-allergic complement pathways appears an attractive therapeutic option in allergic asthma.

Original languageEnglish
JournalCurrent Opinion in Pharmacology
Issue number3
Pages (from-to)283-289
Number of pages7
Publication statusPublished - 01.06.2007


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