Background: The interleukin-4-inducing principle from Schistosoma mansoni eggs (IPSE/α-1) triggers basophils to release interleukin-4 and interleukin-13 in an IgE-dependent but antigen-independent way. Results: Structural analysis identified IPSE/α-1 as a new member of the βγ-crystallin superfamily with a unique IgE-binding loop. Conclusion: IPSE/α-1 activates basophils via IgE-binding crystallin folds. Significance: Schistosomes use unique mechanisms to manipulate the host's immune response.
Research Areas and Centers
- Academic Focus: Center for Infection and Inflammation Research (ZIEL)