A crystallin fold in the interleukin-4-inducing principle of schistosoma mansoni eggs (IPSE/α-1) mediates IgE binding for antigen-independent basophil activation

N. Helge Meyer; Hubert Mayerhofer; Konstantinos Tripsianes; Silke Blindow; Daniela Barths; Astrid Mewes; Thomas Weimar; Thies Köhli; Steffen Bade; Tobias Madl; Andreas Frey; Helmut Haas; Jochen Mueller-Dieckmann; Michael Sattler; Gabriele Schramm

doi:10.1074/jbc.M115.675066

A crystallin fold in the interleukin-4-inducing principle of schistosoma mansoni eggs (IPSE/α-1) mediates IgE binding for antigen-independent basophil activation

N. Helge Meyer, Hubert Mayerhofer, Konstantinos Tripsianes, Silke Blindow, Daniela Barths, Astrid Mewes, Thomas Weimar, Thies Köhli, Steffen Bade, Tobias Madl, Andreas Frey, Helmut Haas, Jochen Mueller-Dieckmann^*, Michael Sattler, Gabriele Schramm

^*Corresponding author for this work

19 Citations (Scopus)

Abstract

Background: The interleukin-4-inducing principle from Schistosoma mansoni eggs (IPSE/α-1) triggers basophils to release interleukin-4 and interleukin-13 in an IgE-dependent but antigen-independent way. Results: Structural analysis identified IPSE/α-1 as a new member of the βγ-crystallin superfamily with a unique IgE-binding loop. Conclusion: IPSE/α-1 activates basophils via IgE-binding crystallin folds. Significance: Schistosomes use unique mechanisms to manipulate the host's immune response.

Original language	English
Journal	Journal of Biological Chemistry
Volume	290
Issue number	36
Pages (from-to)	22111-22126
Number of pages	16
ISSN	0021-9258
DOIs	https://doi.org/10.1074/jbc.M115.675066
Publication status	Published - 04.09.2015

Research Areas and Centers

Academic Focus: Center for Infection and Inflammation Research (ZIEL)

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This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1074/jbc.M115.675066

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Meyer, N. H., Mayerhofer, H., Tripsianes, K., Blindow, S., Barths, D., Mewes, A., Weimar, T., Köhli, T., Bade, S., Madl, T., Frey, A., Haas, H., Mueller-Dieckmann, J., Sattler, M., & Schramm, G. (2015). A crystallin fold in the interleukin-4-inducing principle of schistosoma mansoni eggs (IPSE/α-1) mediates IgE binding for antigen-independent basophil activation. Journal of Biological Chemistry, 290(36), 22111-22126. https://doi.org/10.1074/jbc.M115.675066

@article{dd7187a38a544399a92560bb52ba8339,

title = "A crystallin fold in the interleukin-4-inducing principle of schistosoma mansoni eggs (IPSE/α-1) mediates IgE binding for antigen-independent basophil activation",

abstract = "Background: The interleukin-4-inducing principle from Schistosoma mansoni eggs (IPSE/α-1) triggers basophils to release interleukin-4 and interleukin-13 in an IgE-dependent but antigen-independent way. Results: Structural analysis identified IPSE/α-1 as a new member of the βγ-crystallin superfamily with a unique IgE-binding loop. Conclusion: IPSE/α-1 activates basophils via IgE-binding crystallin folds. Significance: Schistosomes use unique mechanisms to manipulate the host's immune response.",

author = "Meyer, {N. Helge} and Hubert Mayerhofer and Konstantinos Tripsianes and Silke Blindow and Daniela Barths and Astrid Mewes and Thomas Weimar and Thies K{\"o}hli and Steffen Bade and Tobias Madl and Andreas Frey and Helmut Haas and Jochen Mueller-Dieckmann and Michael Sattler and Gabriele Schramm",

year = "2015",

month = sep,

day = "4",

doi = "10.1074/jbc.M115.675066",

language = "English",

volume = "290",

pages = "22111--22126",

journal = "Journal of Biological Chemistry",

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Meyer, NH, Mayerhofer, H, Tripsianes, K, Blindow, S, Barths, D, Mewes, A, Weimar, T, Köhli, T, Bade, S, Madl, T, Frey, A, Haas, H, Mueller-Dieckmann, J, Sattler, M & Schramm, G 2015, 'A crystallin fold in the interleukin-4-inducing principle of schistosoma mansoni eggs (IPSE/α-1) mediates IgE binding for antigen-independent basophil activation', Journal of Biological Chemistry, vol. 290, no. 36, pp. 22111-22126. https://doi.org/10.1074/jbc.M115.675066

A crystallin fold in the interleukin-4-inducing principle of schistosoma mansoni eggs (IPSE/α-1) mediates IgE binding for antigen-independent basophil activation. / Meyer, N. Helge; Mayerhofer, Hubert; Tripsianes, Konstantinos et al.
In: Journal of Biological Chemistry, Vol. 290, No. 36, 04.09.2015, p. 22111-22126.

Research output: Journal Articles › Journal articles › Research › peer-review

TY - JOUR

T1 - A crystallin fold in the interleukin-4-inducing principle of schistosoma mansoni eggs (IPSE/α-1) mediates IgE binding for antigen-independent basophil activation

AU - Meyer, N. Helge

AU - Mayerhofer, Hubert

AU - Tripsianes, Konstantinos

AU - Blindow, Silke

AU - Barths, Daniela

AU - Mewes, Astrid

AU - Weimar, Thomas

AU - Köhli, Thies

AU - Bade, Steffen

AU - Madl, Tobias

AU - Frey, Andreas

AU - Haas, Helmut

AU - Mueller-Dieckmann, Jochen

AU - Sattler, Michael

AU - Schramm, Gabriele

PY - 2015/9/4

Y1 - 2015/9/4

N2 - Background: The interleukin-4-inducing principle from Schistosoma mansoni eggs (IPSE/α-1) triggers basophils to release interleukin-4 and interleukin-13 in an IgE-dependent but antigen-independent way. Results: Structural analysis identified IPSE/α-1 as a new member of the βγ-crystallin superfamily with a unique IgE-binding loop. Conclusion: IPSE/α-1 activates basophils via IgE-binding crystallin folds. Significance: Schistosomes use unique mechanisms to manipulate the host's immune response.

AB - Background: The interleukin-4-inducing principle from Schistosoma mansoni eggs (IPSE/α-1) triggers basophils to release interleukin-4 and interleukin-13 in an IgE-dependent but antigen-independent way. Results: Structural analysis identified IPSE/α-1 as a new member of the βγ-crystallin superfamily with a unique IgE-binding loop. Conclusion: IPSE/α-1 activates basophils via IgE-binding crystallin folds. Significance: Schistosomes use unique mechanisms to manipulate the host's immune response.

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U2 - 10.1074/jbc.M115.675066

DO - 10.1074/jbc.M115.675066

M3 - Journal articles

C2 - 26163514

AN - SCOPUS:84941353131

SN - 0021-9258

VL - 290

SP - 22111

EP - 22126

JO - Journal of Biological Chemistry

JF - Journal of Biological Chemistry

IS - 36

ER -

A crystallin fold in the interleukin-4-inducing principle of schistosoma mansoni eggs (IPSE/α-1) mediates IgE binding for antigen-independent basophil activation

Abstract

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