TY - JOUR
T1 - A comparison of the three year course between chronic depression and depression with multiple vs. few prior episodes
AU - Humer, Elke
AU - Kocsis-Bogar, Krisztina
AU - Berger, Thomas
AU - Schröder, Johanna
AU - Späth, Christina
AU - Meyer, Björn
AU - Moritz, Steffen
AU - Lutz, Wolfgang
AU - Probst, Thomas
AU - Klein, Jan Philipp
N1 - Funding Information:
This work was supported by the German Federal Ministry of Health, II A 5 - 2512 FSB 052. The funding body had no role in the design of the study, data collection, analysis or interpretation of the data.
Publisher Copyright:
© 2020 The Authors
Copyright:
Copyright 2020 Elsevier B.V., All rights reserved.
PY - 2020/9
Y1 - 2020/9
N2 - This study tested the hypothesis that chronic depression (CD) is more similar to depression with multiple prior episodes (ME) than to depression with few prior episodes (FE). Data from participants (n = 1013) with mild to moderate depressive symptoms (Patient Health Questionnaire [PHQ-9] score 5 – 14) who took part in a randomized control trial of an internet intervention for depression (EVIDENT trial) were re-analyzed. The MINI-interview was conducted to diagnose CD (n = 376). If CD was not diagnosed, the self-reported number of depressive episodes was used to categorize participants as having episodic depression with up to five (FE, n = 422) or more than five (ME, n = 215) prior episodes. Over a three-year period, participants were assessed repeatedly regarding the course of depression (PHQ-9, QIDS), quality of life (SF-12) and therapeutic progress (FEP-2). At baseline, most scores were different between CD and FE but comparable between CD and ME. Time to remission did not differ between CD and ME but was longer in CD compared to FE. Results suggest that ME closely resembles CD and that CD differs from FE.
AB - This study tested the hypothesis that chronic depression (CD) is more similar to depression with multiple prior episodes (ME) than to depression with few prior episodes (FE). Data from participants (n = 1013) with mild to moderate depressive symptoms (Patient Health Questionnaire [PHQ-9] score 5 – 14) who took part in a randomized control trial of an internet intervention for depression (EVIDENT trial) were re-analyzed. The MINI-interview was conducted to diagnose CD (n = 376). If CD was not diagnosed, the self-reported number of depressive episodes was used to categorize participants as having episodic depression with up to five (FE, n = 422) or more than five (ME, n = 215) prior episodes. Over a three-year period, participants were assessed repeatedly regarding the course of depression (PHQ-9, QIDS), quality of life (SF-12) and therapeutic progress (FEP-2). At baseline, most scores were different between CD and FE but comparable between CD and ME. Time to remission did not differ between CD and ME but was longer in CD compared to FE. Results suggest that ME closely resembles CD and that CD differs from FE.
UR - http://www.scopus.com/inward/record.url?scp=85086876779&partnerID=8YFLogxK
UR - https://www.mendeley.com/catalogue/85d4758f-c521-333f-ba60-44430010aacf/
U2 - 10.1016/j.psychres.2020.113235
DO - 10.1016/j.psychres.2020.113235
M3 - Journal articles
C2 - 32599445
AN - SCOPUS:85086876779
SN - 0165-1781
VL - 291
SP - 113235
JO - Psychiatry Research
JF - Psychiatry Research
M1 - 113235
ER -