A class of membrane proteins with a C-terminal anchor

Ulrike Kutay*, Enno Hartmann, Tom A. Rapoport

*Corresponding author for this work
214 Citations (Scopus)


Integral membrane proteins are generally targeted to translocation-competent membranes by virtue of signal sequences located close to the N-terminus of the polypeptide chain. Membrane anchoring is caused by the signal sequence or other hydrophobic segments located after it in the amino acid sequence. However, some integral membrane proteins do not follow these rules. The members of one class of nonconformist membrane proteins have no signal sequence, but instead possess a hydrophobic segment near the C-terminus that orients them with their N-termini in the cytoplasm. Members of this class are found in many organelles and are probably inserted into membranes by an unusual mechanism.

Original languageEnglish
JournalTrends in Cell Biology
Issue number3
Pages (from-to)72-75
Number of pages4
Publication statusPublished - 01.01.1993


Dive into the research topics of 'A class of membrane proteins with a C-terminal anchor'. Together they form a unique fingerprint.

Cite this