A bioinformatic assay for pluripotency in human cells

Franz Josef Müller*, Bernhard M. Schuldt, Roy Williams, Dylan Mason, Gulsah Altun, Eirini P. Papapetrou, Sandra Danner, Johanna E. Goldmann, Arne Herbst, Nils O. Schmidt, Josef B. Aldenhoff, Louise C. Laurent, Jeanne F. Loring

*Corresponding author for this work
230 Citations (Scopus)


Pluripotent stem cells (PSCs) are defined by their potential to generate all cell types of an organism. The standard assay for pluripotency of mouse PSCs is cell transmission through the germline, but for human PSCs researchers depend on indirect methods such as differentiation into teratomas in immunodeficient mice. Here we report PluriTest, a robust open-access bioinformatic assay of pluripotency in human cells based on their gene expression profiles.

Original languageEnglish
JournalNature Methods
Issue number4
Pages (from-to)315-317
Number of pages3
Publication statusPublished - 01.04.2011
Externally publishedYes


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