48-hour rapid cycling: results of psychopathometric, polysomnographic, PET imaging and neuro-endocrine longitudinal investigations in a single case

H. Gann; D. Riemann; F. Hohagen; L. G. Strauss; H. Dressing; W. E. Müller; M. Berger

doi:10.1016/0165-0327(93)90042-I

48-hour rapid cycling: results of psychopathometric, polysomnographic, PET imaging and neuro-endocrine longitudinal investigations in a single case

H. Gann, D. Riemann, F. Hohagen, L. G. Strauss, H. Dressing, W. E. Müller, M. Berger

Clinic of Psychiatry and Psychotherapy

University of Mannheim

20 Citations (Scopus)

Abstract

We report a 64-year-old patient suffering from rapid cycling bipolar disorder who was studied by means of polysomnography, neuroendocrine tests and PET (position emission tomography) imaging. In a manner only partly compatible with the cholinergic-aminergic imbalance model of mania and depression, a linkage of REM sleep disinhibition and depressive mood was observed, but no decisive REM sleep delay was seen on manic days. Growth hormone secretion after clonidine stimulation was blunted on depressive and hypomanic days. A series of total sleep deprivations led to a postive effect on psychopathology for about two weeks. Carbamazepine treatment normalized REM sleep variables, damped the amplitude of mood cycling of the patient, increased TSH and decreased FT₄.

Original language	English
Journal	Journal of Affective Disorders
Volume	28
Issue number	2
Pages (from-to)	133-140
Number of pages	8
ISSN	0165-0327
DOIs	https://doi.org/10.1016/0165-0327(93)90042-I
Publication status	Published - 06.1993

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Academic Focus: Center for Brain, Behavior and Metabolism (CBBM)

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title = "48-hour rapid cycling: results of psychopathometric, polysomnographic, PET imaging and neuro-endocrine longitudinal investigations in a single case",

abstract = "We report a 64-year-old patient suffering from rapid cycling bipolar disorder who was studied by means of polysomnography, neuroendocrine tests and PET (position emission tomography) imaging. In a manner only partly compatible with the cholinergic-aminergic imbalance model of mania and depression, a linkage of REM sleep disinhibition and depressive mood was observed, but no decisive REM sleep delay was seen on manic days. Growth hormone secretion after clonidine stimulation was blunted on depressive and hypomanic days. A series of total sleep deprivations led to a postive effect on psychopathology for about two weeks. Carbamazepine treatment normalized REM sleep variables, damped the amplitude of mood cycling of the patient, increased TSH and decreased FT4.",

author = "H. Gann and D. Riemann and F. Hohagen and Strauss, {L. G.} and H. Dressing and M{\"u}ller, {W. E.} and M. Berger",

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AU - Gann, H.

AU - Riemann, D.

AU - Hohagen, F.

AU - Strauss, L. G.

AU - Dressing, H.

AU - Müller, W. E.

AU - Berger, M.

N1 - Funding Information: This study was supported by a grant from the DFG (SFB 258, Al).

PY - 1993/6

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AB - We report a 64-year-old patient suffering from rapid cycling bipolar disorder who was studied by means of polysomnography, neuroendocrine tests and PET (position emission tomography) imaging. In a manner only partly compatible with the cholinergic-aminergic imbalance model of mania and depression, a linkage of REM sleep disinhibition and depressive mood was observed, but no decisive REM sleep delay was seen on manic days. Growth hormone secretion after clonidine stimulation was blunted on depressive and hypomanic days. A series of total sleep deprivations led to a postive effect on psychopathology for about two weeks. Carbamazepine treatment normalized REM sleep variables, damped the amplitude of mood cycling of the patient, increased TSH and decreased FT4.

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48-hour rapid cycling: results of psychopathometric, polysomnographic, PET imaging and neuro-endocrine longitudinal investigations in a single case

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